INT240463

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 43 99.12 Very High Very High Very High
Pain 69 92.16 High High
Arthritis 43 91.96 High High
amygdala 97 90.96 High High
spinal dorsal horn 2 85.72 High High
spinothalamic tract 3 71.28 Quite High
Dorsal horn 2 71.12 Quite High
long-term potentiation 4 68.32 Quite High
addiction 3 58.52 Quite High
Dorsal horn neuron 2 46.92 Quite Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 1 93.12 High High
Pain 69 92.16 High High
Arthritis 63 91.96 High High
Myocardial Infarction 1 91.68 High High
Nociception 5 84.16 Quite High
Targeted Disruption 3 17.24 Low Low
Hypersensitivity 1 7.04 Low Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blocking phosphorylation with PKA and ERK inhibitors would shift the balance from phosphorylation toward dephosphorylation by constitutively active phosphatases [71].
Negative_regulation (Blocking) of Phosphorylation (phosphorylation) of PKA
1) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2490682 Disease Relevance 0.41 Pain Relevance 0.97
PKA phosphorylation desensitised the myofilaments in all groups.The magnitude of this effect depended on the endogenous phosphorylation levels since similar pCa50 values were attained after PKA treatment.
Negative_regulation (desensitised) of Phosphorylation (phosphorylation) of PKA
2) Confidence 0.13 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

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