INT240484

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) extracellular region (Col7a1)
cell adhesion (Col7a1) proteinaceous extracellular matrix (Col7a1) lysosome (Ctsk)
Anatomy Link Frequency
lung 2
Ctsk (Mus musculus)
Col7a1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 26 88.52 High High
Inflammation 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 25 95.44 Very High Very High Very High
Pulmonary Fibrosis 23 88.52 High High
Apoptosis 1 68.08 Quite High
Disease 4 55.52 Quite High
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Fibrosis 5 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low
Pulmonary Disease 2 5.00 Very Low Very Low Very Low
Cicatrix 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More specifically, we found that cathepsin K knockout mice (CTSK-/-) deposited significantly more extracellular matrix upon bleomycin challenge than control mice, and primary lung fibroblasts derived from these animals showed a decreased collagenolytic activity, thus supporting a role for cathepsin K in lung collagen degradation.
cathepsin K Positive_regulation (role) of Protein_catabolism (degradation) of collagen in lung associated with targeted disruption
1) Confidence 0.12 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.42 Pain Relevance 0.07

General Comments

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