INT240518

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
fibroblast 2
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 10 85.68 High High
GABAergic 1 51.00 Quite High
gABA 1 47.32 Quite Low
Kinase C 1 46.04 Quite Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 98.64 Very High Very High Very High
Ganglion Cysts 2 93.04 High High
Apoptosis 5 86.24 High High
INFLAMMATION 10 85.68 High High
Adhesions 3 82.72 Quite High
Stress 3 26.56 Quite Low
Calcification 1 25.96 Quite Low
Increased Venous Pressure Under Development 1 25.76 Quite Low
Ocular Hypertension 1 5.24 Low Low
Injury 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data agree with a previous report of upregulated Fgf2 protein levels after 3 months of diabetes in the Sprague Dawley rat [54].
Negative_regulation (report) of Positive_regulation (upregulated) of Fgf2 associated with diabetes mellitus
1) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.66 Pain Relevance 0.07
They also reported a substantial increase in the expression of fibroblast growth factor 2 (FGF-2), a potent stimulator of angiogenesis, and showed that anti-FGF-2 antibodies inhibited the effects of the electromagnetic energy.22 This upregulation of FGF-2 in endothelial cells exposed to pulsed electromagnetic fields was recently confirmed by Callaghan et al.23 Roland et al used pulsed magnetic energy to stimulate neovascularization in a rat model.24 Weber et al demonstrated increased survival of rat groin composite flaps supported by an arterial loop, again showing that pulsed magnetic fields promote neovascularization.25
Negative_regulation (inhibited) of Positive_regulation (upregulation) of FGF-2 in fibroblast
2) Confidence 0.24 Published 2008 Journal Eplasty Section Body Doc Link PMC2490801 Disease Relevance 0 Pain Relevance 0

General Comments

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