INT240542

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.11
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TBX21) DNA binding (TBX21)
Anatomy Link Frequency
naive T cells 1
T-cells 1
TBX21 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 96.88 Very High Very High Very High
Demyelination 10 80.96 Quite High
Central nervous system 94 80.68 Quite High
agonist 90 78.88 Quite High
Inflammation 134 74.12 Quite High
Multiple sclerosis 50 47.36 Quite Low
Crohn's disease 8 40.80 Quite Low
tolerance 26 29.28 Quite Low
Spinal cord 12 19.80 Low Low
COX2 2 5.36 Low Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 32 97.44 Very High Very High Very High
Targeted Disruption 12 95.84 Very High Very High Very High
Multiple Sclerosis 72 94.16 High High
Wasting Syndrome 2 93.32 High High
Inflammatory Bowel Disease 60 85.28 High High
Disease 162 84.80 Quite High
Demyelinating Disease 62 80.96 Quite High
INFLAMMATION 142 74.12 Quite High
Diarrhoea 2 67.56 Quite High
Colitis 16 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
cells, resulting in the induction of T-bet in naive T cells [102].
Positive_regulation (induction) of T-bet in naive T cells
1) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.27 Pain Relevance 0.14
are potent inducers of T-bet,
Positive_regulation (inducers) of T-bet
2) Confidence 0.45 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.01 Pain Relevance 0.41
IL-17A can also modulate the TH1 polarization in vitro in inhibitory sense, suppressing the induction of the transcriptional factor T-bet, the “master regulator” of TH1 differentiation of T-cells.
Positive_regulation (induction) of T-bet in T-cells
3) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.70 Pain Relevance 0.12
These transcription factors include T-bet for TH1 cells, and GATA-3 for TH2 cells [62].
Positive_regulation (include) of T-bet
4) Confidence 0.06 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.13 Pain Relevance 0.22

General Comments

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