INT240593

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.01
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Naip1) cytoplasm (Naip1)
Anatomy Link Frequency
Macrophage 1
Naip1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 78 100.00 Very High Very High Very High
metalloproteinase 6 100.00 Very High Very High Very High
cytokine 12 65.60 Quite High
Inflammatory response 3 15.80 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 100.00 Very High Very High Very High
Apoptosis 15 100.00 Very High Very High Very High
Osteogenic Sarcomas 6 100.00 Very High Very High Very High
Down Syndrome 6 100.00 Very High Very High Very High
Periodontitis 48 99.42 Very High Very High Very High
Hemorrhage 9 85.44 High High
Chronic Periodontitis 9 71.20 Quite High
Infection 3 48.12 Quite Low
Dental Plaque 3 35.04 Quite Low
Wound Healing 3 31.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of BIRC-1, a potent inhibitor of activated caspase-3 and -7 [26] and the decreased expression of RIP-2, a strong activator of NF-?
Gene_expression (expression) of BIRC-1
1) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.44 Pain Relevance 0.14
(Cxcl-3), Inhibitor of apoptosis protein-1 (BIRC-1), Cluster of differentiation antigen 38 (CD38), Regulator of G-protein signalling-1 (RGS-1), and Finkel-Biskis-Jinkins murine osteosarcoma virus oncogene (C-FOS); the 5% least strongly expressed genes were Receptor-interacting Serine/Threonine Kinase-2 (RIP-2), Complement component 3 (C3), Prostaglandin-endoperoxide synthase-2 (COX-2), Interleukin-8 (IL-8), Endothelin-1 (EDN-1), Plasminogen activator inhibitor type-2 (PAI-2), Matrix-metalloproteinase-14 (MMP-14), and Interferon regulating factor-7 (IRF-7).


Gene_expression (expressed) of BIRC-1 associated with metalloproteinase, osteogenic sarcomas and apoptosis
2) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2491649 Disease Relevance 0.73 Pain Relevance 0.19
In gingival tissues from treated periodontitis sites, the 5% most strongly expressed genes were Interleukin-12A (IL-12A, NM_000882, 3.1-fold), Versican (CSPG-2, NM_004385, 3.35-fold), Matrix metalloproteinase-1 (MMP-1, NM_002421, 3.37-fold), Down syndrome critical region protein-1 (DSCR-1, NM_004414, 3.79-fold), Macrophage inflammatory protein-2beta (cxcl-3, NM_002090, 3.99-fold), Inhibitor of apoptosis protein-1 (BIRC-1, NM_004536, 4.04-fold), Cluster of differentiation antigen 38 (CD38, NM_001775, 4.43-fold), Regulator of G-protein signalling-1 (RGS-1, NM_002922, 5.53-fold), and Finkel-Biskis-Jinkins murine osteosarcoma virus oncogene (C-FOS, NM_005252, 5.65-fold).
Gene_expression (expressed) of BIRC-1 in Macrophage associated with down syndrome, periodontitis, inflammation, metalloproteinase, osteogenic sarcomas and apoptosis
3) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.85 Pain Relevance 0.16

General Comments

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