INT240595

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Macrophage 2
CSPG4P2Y (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 98.72 Very High Very High Very High
Inflammation 78 96.04 Very High Very High Very High
Inflammatory response 3 15.80 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontitis 48 99.42 Very High Very High Very High
Down Syndrome 6 98.48 Very High Very High Very High
INFLAMMATION 81 96.04 Very High Very High Very High
Apoptosis 15 90.48 High High
Hemorrhage 9 85.44 High High
Osteogenic Sarcomas 6 81.68 Quite High
Chronic Periodontitis 9 81.56 Quite High
Infection 3 58.48 Quite High
Dental Plaque 3 35.04 Quite Low
Periodontal Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Out of the 136 genes analyzed, the 5% most strongly expressed genes compared to healthy controls were Interleukin-12A (IL-12A), Versican (CSPG-2), Matrixmetalloproteinase-1 (MMP-1), Down syndrome critical region protein-1 (DSCR-1), Macrophage inflammatory protein-2?
Gene_expression (expressed) of CSPG-2 in Macrophage associated with down syndrome and inflammation
1) Confidence 0.03 Published 2008 Journal BMC Med Genomics Section Abstract Doc Link PMC2491649 Disease Relevance 0.86 Pain Relevance 0.19
In gingival tissues from treated periodontitis sites, the 5% most strongly expressed genes were Interleukin-12A (IL-12A, NM_000882, 3.1-fold), Versican (CSPG-2, NM_004385, 3.35-fold), Matrix metalloproteinase-1 (MMP-1, NM_002421, 3.37-fold), Down syndrome critical region protein-1 (DSCR-1, NM_004414, 3.79-fold), Macrophage inflammatory protein-2beta (cxcl-3, NM_002090, 3.99-fold), Inhibitor of apoptosis protein-1 (BIRC-1, NM_004536, 4.04-fold), Cluster of differentiation antigen 38 (CD38, NM_001775, 4.43-fold), Regulator of G-protein signalling-1 (RGS-1, NM_002922, 5.53-fold), and Finkel-Biskis-Jinkins murine osteosarcoma virus oncogene (C-FOS, NM_005252, 5.65-fold).
Gene_expression (expressed) of CSPG-2 in Macrophage associated with down syndrome, periodontitis, inflammation, metalloproteinase, osteogenic sarcomas and apoptosis
2) Confidence 0.02 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.82 Pain Relevance 0.16
For the validation of the expression analysis real-time-PCR of five highly expressed genes (RGS-1, CD38, C-FOS, DSCR-1, CSPG-2) was performed.
Gene_expression (expressed) of CSPG-2
3) Confidence 0.01 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.19 Pain Relevance 0.06

General Comments

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