INT240596

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.91
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2)
cytoplasm (RIPK2) signal transducer activity (RIPK2)
RIPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 52 96.00 Very High Very High Very High
cytokine 8 62.24 Quite High
metalloproteinase 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 97.48 Very High Very High Very High
Periodontitis 32 97.18 Very High Very High Very High
INFLAMMATION 54 96.00 Very High Very High Very High
Wound Healing 2 64.88 Quite High
Chronic Periodontitis 6 5.00 Very Low Very Low Very Low
Hemorrhage 6 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 4 5.00 Very Low Very Low Very Low
Down Syndrome 4 5.00 Very Low Very Low Very Low
Periodontal Disease 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased expression of BIRC-1, a potent inhibitor of activated caspase-3 and -7 [26] and the decreased expression of RIP-2, a strong activator of NF-?
Negative_regulation (decreased) of Gene_expression (expression) of RIP-2
1) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.40 Pain Relevance 0.11
It has been described that in untreated periodontitis sites, the activity of caspase-3, -7, and Fas is increased compared to healthy tissues [28] and thus the up-regulation of BIRC-1 as well as decreased expression of RIP-2 may represent different protective host mechanisms to control apoptotic processes following periodontal therapy.
Negative_regulation (decreased) of Gene_expression (expression) of RIP-2 associated with periodontitis and apoptosis
2) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.50 Pain Relevance 0.04

General Comments

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