INT2406

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 9
Speculated 3
Reported most in Abstract
Documents 85
Total Number 88
Disease Relevance 28.04
Pain Relevance 46.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCK) extracellular space (CCK) extracellular region (CCK)
Anatomy Link Frequency
plasma 12
SK-N-MC 4
salivary gland epithelium 4
brain 3
bowel 3
CCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 1096 100.00 Very High Very High Very High
Chronic pancreatitis 197 100.00 Very High Very High Very High
Neuropeptide 99 100.00 Very High Very High Very High
Enkephalin 89 100.00 Very High Very High Very High
Somatostatin 52 100.00 Very High Very High Very High
antagonist 46 100.00 Very High Very High Very High
substance P 37 100.00 Very High Very High Very High
spastic colon 16 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
agonist 10 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 200 100.00 Very High Very High Very High
Disease 27 100.00 Very High Very High Very High
Pancreatic Cancer 10 100.00 Very High Very High Very High
Functional Bowel Disorder 9 100.00 Very High Very High Very High
Gallbladder Disease 4 100.00 Very High Very High Very High
Critical Illness 485 99.84 Very High Very High Very High
Small Cell Lung Cancer 20 99.78 Very High Very High Very High
Peripheral Primitive Neuroectodermal Tumors 26 99.56 Very High Very High Very High
Pancreatic Fistula 2 99.54 Very High Very High Very High
Gastrointestinal Disease 16 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCK produces satiety not only in animals but also in man: it reduces appetite and activation arising from the preparation of a meal and inhibits intake of liquid and solid food in both lean and obese subjects.
Gene_expression (produces) of CCK associated with obesity and cholecystokinin
1) Confidence 0.78 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 3085129 Disease Relevance 0.17 Pain Relevance 0.45
The aim of this study was to investigate the ultrastructural appearance of pancreatic adenocarcinoma combined with glucagon and gastrin/cholecystokinin (CCK) expression.
Gene_expression (expression) of CCK associated with adenocarcinoma and cholecystokinin
2) Confidence 0.78 Published 2007 Journal Ultrastruct Pathol Section Abstract Doc Link 17786831 Disease Relevance 0.57 Pain Relevance 0.27
Increased and ectopic gastrin/CCK expression was correlated with pancreatic adenocarcinomas exhibiting poor histological grade and neoplastic endocrine cells, providing a potential marker for pancreatic adenocarcinomas with aggressive behavior.
Gene_expression (expression) of CCK in endocrine cells associated with adenocarcinoma, aggression and cholecystokinin
3) Confidence 0.78 Published 2007 Journal Ultrastruct Pathol Section Abstract Doc Link 17786831 Disease Relevance 1.22 Pain Relevance 0.24
The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line.
Gene_expression (co-expressed) of cholecystokinin gene associated with peripheral primitive neuroectodermal tumors, neuropeptide, enkephalin and cholecystokinin
4) Confidence 0.77 Published 1990 Journal FEBS Lett. Section Title Doc Link 2384178 Disease Relevance 0.19 Pain Relevance 0.82
The observation that the rate of GE is inversely related to the fasting levels of CCK and PYY suggests that they may contribute to the regulation of GE in critically ill patients.
Gene_expression (levels) of CCK associated with critical illness and cholecystokinin
5) Confidence 0.77 Published 2007 Journal Crit Care Section Body Doc Link PMC2246231 Disease Relevance 0.71 Pain Relevance 0.21
Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and in man significant quantities are expressed in all regions of the brain.1,2 Therefore, CCK has been implicated in a variety of CNS functions-such as feeding behavior, anxiety, analgesia and memory functions as well as psychiatric disease like panic disorder and schizophrenia (for review, see2,3).
Gene_expression (expressed) of CCK in brain associated with panic disorder, mental disorders, anxiety disorder, neuropeptide, cholecystokinin, schizophrenia and analgesia
6) Confidence 0.77 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.57 Pain Relevance 0.43
Cholecystokinin (CCK) is the most abundant neuropeptide in the mammalian brain, and in man significant quantities are expressed in all regions of the brain.1,2 Therefore, CCK has been implicated in a variety of CNS functions-such as feeding behavior, anxiety, analgesia and memory functions as well as psychiatric disease like panic disorder and schizophrenia (for review, see2,3).
Gene_expression (expressed) of Cholecystokinin in brain associated with panic disorder, mental disorders, anxiety disorder, neuropeptide, cholecystokinin, schizophrenia and analgesia
7) Confidence 0.77 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.57 Pain Relevance 0.43
Recently, a number of studies have indicated that a C-36 to T transition in the CCK gene promoter Sp1 element4 (Figure 1) is associated with alcoholism and withdrawal symptoms as well as panic disorder.5-7 Moreover, it has been proposed that the polymorphism plays a direct role in the pathogenesis of the disorders by decreasing the expression and synthesis of CCK peptides.
Gene_expression (expression) of CCK associated with panic disorder, alcohol addiction, withdrawal and cholecystokinin
8) Confidence 0.77 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889557 Disease Relevance 0.77 Pain Relevance 0.45
In humans, CCK infusions, which produce plasma CCK levels similar to those seen postprandially, stimulate the pancreas predominantly via a pathway dependent on cholinergic innervation.
Gene_expression (produce) of CCK in pancreas associated with cholecystokinin
9) Confidence 0.77 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.80
CCK-8 at 10 ng.kg-1.h-1 produced plasma CCK levels similar to postprandial levels (6.0 +/- 1.3 vs. 6.9 +/- 0.8 pM), whereas the 40-ng.kg-1.h-1 dose produced supraphysiological levels (18.4 +/- 3.1 pM).
Gene_expression (produced) of CCK in plasma associated with cholecystokinin
10) Confidence 0.77 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1636705 Disease Relevance 0 Pain Relevance 0.70
Expression of the cholecystokinin gene in a human (small-cell) lung carcinoma cell-line.
Gene_expression (Expression) of cholecystokinin in lung associated with lung cancer, enkephalin and cholecystokinin
11) Confidence 0.77 Published 1990 Journal FEBS Lett. Section Title Doc Link 1977617 Disease Relevance 0.52 Pain Relevance 0.62
Expression of the cholecystokinin (CCK), gastrin and enkephalin A genes were studied by Northern blot analysis and a library of sequence-specific radioimmunoassays in human cell lines.
Gene_expression (Expression) of CCK associated with enkephalin and cholecystokinin
12) Confidence 0.77 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.45 Pain Relevance 0.44
Thus, the human small cell carcinoma cell line U-1690 is a useful model for studies of cell-specific CCK gene expression.
Gene_expression (expression) of CCK associated with small cell lung cancer and cholecystokinin
13) Confidence 0.77 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.59 Pain Relevance 0.49
Expression of the cholecystokinin (CCK), gastrin and enkephalin A genes were studied by Northern blot analysis and a library of sequence-specific radioimmunoassays in human cell lines.
Gene_expression (Expression) of cholecystokinin associated with enkephalin and cholecystokinin
14) Confidence 0.77 Published 1990 Journal FEBS Lett. Section Abstract Doc Link 1977617 Disease Relevance 0.45 Pain Relevance 0.44
There was no correlation between basal and postprandial levels of cholecystokinin and somatostatin in our study.
Gene_expression (levels) of cholecystokinin
15) Confidence 0.76 Published 2000 Journal Hepatogastroenterology Section Body Doc Link 10919050 Disease Relevance 0 Pain Relevance 0
Cholecystokinin, OP-CCK, and gastrin produced maximal stimulatory effects at 7.5 x 10(-9), 4.5 x 10(-9), and 3.5 x 10(-9) M, respectively.
Gene_expression (produced) of Cholecystokinin associated with cholecystokinin
16) Confidence 0.76 Published 1979 Journal Am. J. Physiol. Section Abstract Doc Link 434148 Disease Relevance 0 Pain Relevance 0.43
Parvalbumin-, but not somatostatin-, calbindin-, or cholecystokinin-expressing interneurons were preferred synaptic targets.
Gene_expression (expressing) of cholecystokinin in interneurons associated with somatostatin and cholecystokinin
17) Confidence 0.75 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18829959 Disease Relevance 0.07 Pain Relevance 0.59
CCK-A receptors are found predominantly in peripheral tissues but they also exist in discrete regions of the primate CNS, including the spinal cord.
Gene_expression (found) of CCK in spinal cord associated with central nervous system and spinal cord
18) Confidence 0.73 Published 1989 Journal Pain Section Abstract Doc Link 2694075 Disease Relevance 0.45 Pain Relevance 0.79
In addition, expression of some neuropeptides such as vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), and substance P in the human salivary gland epithelium during the gestational period was observed, whereas the other polypeptides examined, including glucagon, cholecystokinin (CCK), Leu-enkephalin, and calcitonin were absent.
Spec (observed) Gene_expression (expression) of CCK in salivary gland epithelium associated with somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
19) Confidence 0.71 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.07 Pain Relevance 0.47
In addition, expression of some neuropeptides such as vasoactive intestinal polypeptide (VIP), somatostatin (SRIF), and substance P in the human salivary gland epithelium during the gestational period was observed, whereas the other polypeptides examined, including glucagon, cholecystokinin (CCK), Leu-enkephalin, and calcitonin were absent.
Spec (observed) Gene_expression (expression) of cholecystokinin in salivary gland epithelium associated with somatostatin, neuropeptide, enkephalin, cholecystokinin and substance p
20) Confidence 0.71 Published 1989 Journal J. Histochem. Cytochem. Section Abstract Doc Link 2471726 Disease Relevance 0.07 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox