INT240619

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 10.74
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, ADIPOQ) extracellular region (CRP, ADIPOQ) generation of precursor metabolites and energy (ADIPOQ)
endoplasmic reticulum (ADIPOQ)
Anatomy Link Frequency
plaque 2
heart 1
CRP (Homo sapiens)
ADIPOQ (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 142 98.00 Very High Very High Very High
Inflammatory marker 14 95.12 Very High Very High Very High
Angina 17 60.88 Quite High
chemokine 7 49.88 Quite Low
cytokine 9 14.60 Low Low
Disease Link Frequency Relevance Heat
Obesity 412 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 138 100.00 Very High Very High Very High
Diabetes Mellitus 43 100.00 Very High Very High Very High
Nicotine Addiction 43 100.00 Very High Very High Very High
Coronary Artery Disease 36 100.00 Very High Very High Very High
Atherosclerosis 34 100.00 Very High Very High Very High
Hypertension 8 100.00 Very High Very High Very High
Heart Rate Under Development 22 99.32 Very High Very High Very High
Coronary Heart Disease 42 99.08 Very High Very High Very High
INFLAMMATION 163 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adiponectin failed to be linked with
    CRP and HDL and was positively associated with apo B in women, contrasted to men. 
CRP Binding (linked) of Adiponectin associated with disorder of lipid metabolism
1) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.85 Pain Relevance 0.10
Our data support the concept that adiponectin is an important marker in the pathogenesis of atherosclerosis since adiponectin remains significantly associated with plaque morphology in a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume.
hsCRP Binding (associated) of adiponectin in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerosis, hypertension, obesity and disorder of lipid metabolism
2) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.40 Pain Relevance 0.03
Our data support the concept that adiponectin is an important marker in the pathogenesis of atherosclerosis since adiponectin remains significantly associated with plaque morphology in a fully adjusted multivariate model containing age, sex, BMI, hypertension, diabetes mellitus, smoking, family history of CAD, LDL-C, HDL-C, triglycerides, hsCRP, medication and PAT volume.
hsCRP Binding (associated) of adiponectin in plaque associated with heart rate under development, coronary artery disease, nicotine addiction, diabetes mellitus, atherosclerosis, hypertension, obesity and disorder of lipid metabolism
3) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649379 Disease Relevance 1.42 Pain Relevance 0.03
This is in essential agreement
    with the recent report on the association of adiponectin in Japanese men with CRP independently
    of all MetS factors 24. 
CRP Binding (association) of adiponectin
4) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.21 Pain Relevance 0.14
In
   multivariable linear analyses, adiponectin levels were significantly associated with
   HDL-cholesterol and CRP, independent of BMI and fasting insulin levels only in men while being
   in women positively associated with apo B, an inflammatory marker 15, and with SHBG. 
CRP Binding (associated) of adiponectin associated with inflammatory marker, obesity and disorder of lipid metabolism
5) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 0.94 Pain Relevance 0.12
In studying a large sample of patients with
    coronary heart disease, van Eynatten et al. 26 found a
    lack of association of adiponectin with CRP which they attributed to a potential decrease of
    the role of systemic inflammation as part of the relationship of adiponectin with
    atherosclerosis during the course of the disease.
CRP Binding (association) of adiponectin in heart associated with inflammation, disease, increased venous pressure under development and coronary heart disease
6) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.42 Pain Relevance 0.11
Present findings indicate that expected associations of adiponectin concentrations with
    HDL-cholesterol and CRP in men is independent of variations in SHBG and other relevant
    parameters such as obesity, insulin level and smoking status. 
CRP Binding (concentrations) of adiponectin associated with nicotine addiction, obesity and disorder of lipid metabolism
7) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.06 Pain Relevance 0.07
Present findings indicate that expected associations of adiponectin concentrations with
    HDL-cholesterol and CRP in men is independent of variations in SHBG and other relevant
    parameters such as obesity, insulin level and smoking status. 
CRP Binding (associations) of adiponectin associated with nicotine addiction, obesity and disorder of lipid metabolism
8) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.06 Pain Relevance 0.08
Thus, the aim of this study was to evaluate: 1) the nature and linearity of the association
   between different indicators of obesity and serum adiponectin levels, 2) whether or not
   anticipated inverse associations between adiponectin and HDL-cholesterol, triglycerides/apo B
   and CRP exist independent of BMI or waist circumference, 3) whether SHBG plays an independent
   role on concentrations of adiponectin in Turkish men and women in whom both atherogenic
   dyslipidemia and MetS prevail 11.


CRP Neg (not) Binding (associations) of adiponectin associated with obesity and disorder of lipid metabolism
9) Confidence 0.13 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.03 Pain Relevance 0.09

General Comments

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