INT240620

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.35
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (INS, SHBG) extracellular space (INS) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
INS (Homo sapiens)
SHBG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 60 89.20 High High
cytokine 4 21.20 Low Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 21 100.00 Very High Very High Very High
Metabolic Syndrome 18 100.00 Very High Very High Very High
Metabolic Disorder 6 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 56 95.76 Very High Very High Very High
Endometriosis (extended) 6 92.36 High High
Cardiovascular Disease 3 92.16 High High
Obesity 168 90.40 High High
INFLAMMATION 70 89.20 High High
Pre-eclampsia 100 88.08 High High
Hyperinsulinism 5 86.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Production of SHBG is inhibited by insulin; therefore, low levels of SHBG are associated with elevated insulin levels.
insulin Binding (associated) of SHBG
1) Confidence 0.12 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 1.41 Pain Relevance 0
In a linear regression analysis for WC (or BMI) in a subset of
    the sample in which serum sex hormone-binding globulin (SHBG) was available and which
    additionally comprised adiponectin, fasting insulin and other confounders, only insulin and, in
    women SHBG, were significantly associated, but not adiponectin. 
insulin Binding (associated) of SHBG
2) Confidence 0.03 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2491727 Disease Relevance 0.41 Pain Relevance 0.04
In linear regression analyses
    for covariates of adiponectin in two models comprising 12 variables, insulin and SHBG
    concentrations were significantly associated in both genders though not BMI. 
insulin Binding (associated) of SHBG
3) Confidence 0.03 Published 2008 Journal International Journal of Biological Sciences Section Abstract Doc Link PMC2491727 Disease Relevance 0.47 Pain Relevance 0.04
This
    observation supports our recent report that low SHBG levels significantly associate,
    particularly in women, with various metabolic disorders, independent of abdominal obesity and
    insulin resistance 10 and suggests that this effect is
    mediated by adiponectin.


insulin Binding (associate) of SHBG associated with metabolic disorder, metabolic syndrome and insulin resistance
4) Confidence 0.03 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2491727 Disease Relevance 1.06 Pain Relevance 0.07

General Comments

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