INT24064

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Context Info
Confidence 0.60
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.74
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
Anatomy Link Frequency
plasma 1
HAF 1
F12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 15 99.40 Very High Very High Very High
Opioid 1 98.16 Very High Very High Very High
antagonist 1 94.52 High High
opiate 1 94.08 High High
rheumatoid arthritis 3 92.80 High High
narcan 3 92.32 High High
Pain 3 85.20 High High
anesthesia 1 76.92 Quite High
b2 receptor 2 70.68 Quite High
Osteoarthritis 1 61.76 Quite High
Disease Link Frequency Relevance Heat
Gram Positive Bacterium Infection 3 98.56 Very High Very High Very High
Pressure Volume 2 Under Development 3 95.80 Very High Very High Very High
Hypotension 2 95.64 Very High Very High Very High
Sepsis 3 90.52 High High
Disease 6 89.40 High High
Infection 6 88.28 High High
Shock 3 86.04 High High
Bacterial Respiratory Disease 3 85.56 High High
Pressure And Volume Under Development 11 85.48 High High
Pain 3 85.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the contact activation of endogenous Hageman factor could result in the generation of vasoactive opioid peptides derived from circulating large molecular weight precursors.
Positive_regulation (activation) of Hageman factor associated with opioid
1) Confidence 0.60 Published 1982 Journal Life Sci. Section Abstract Doc Link 6815399 Disease Relevance 0.26 Pain Relevance 0.37
This results in consumption of C1Inh; the decrease of C1Inh levels correlating with the increase in Hageman factor [15,16].
Positive_regulation (increase) of Hageman factor
2) Confidence 0.43 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2918592 Disease Relevance 0.11 Pain Relevance 0.23
However, the ability of the solid-phase assay to detect and quantitate alpha 2M-proteinase complexes when they are present was confirmed in control experiments with plasma samples to which performed alpha 2M-trypsin complexes had been added, or in which alpha 2M-kallikrein complexes had been generated by activation of Hageman factor (coagulation factor XII).
Positive_regulation (activation) of Hageman factor in plasma
3) Confidence 0.16 Published 1987 Journal Arthritis Rheum. Section Abstract Doc Link 2443146 Disease Relevance 0.26 Pain Relevance 0.21
Although retransfusion led to an increase of LBF, HAF and PVF in both groups, the restauration was significantly better in PBZ-treated animals.
Positive_regulation (increase) of HAF in HAF
4) Confidence 0.13 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3425331 Disease Relevance 0.52 Pain Relevance 0.11
It is also noteworthy that bacterial cell wall components themselves, i.e. endotoxin (or lipopolysaccharide) of gram negative bacteria and teichoic/lipoteichoic acid of gram positive bacteria, are also able to activate the bradykinin generating cascade-involving activation of Hageman factor as mentioned above.
Positive_regulation (activation) of Hageman factor associated with gram positive bacterium infection and bradykinin
5) Confidence 0.08 Published 1996 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 8737987 Disease Relevance 0.41 Pain Relevance 0.11
Hageman factor-->activated Hageman factor-->prekallikrein-->kallikrein-->high-molecular weight kininogen-->bradykinin.
Positive_regulation (activated) of Hageman factor associated with bradykinin
6) Confidence 0.07 Published 1996 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 8737987 Disease Relevance 0.59 Pain Relevance 0.18
Hageman factor-->activated Hageman factor-->prekallikrein-->kallikrein-->high-molecular weight kininogen-->bradykinin.
Positive_regulation (activated) of Hageman factor associated with bradykinin
7) Confidence 0.06 Published 1996 Journal Biol. Chem. Hoppe-Seyler Section Abstract Doc Link 8737987 Disease Relevance 0.59 Pain Relevance 0.18

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