INT240658

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Context Info
Confidence 0.33
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.67
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ngf, Ngf, Bdnf) signal transduction (Ngf, Ngf) extracellular space (Ngf, Ngf)
aging (Ngf, Ngf) molecular_function (Ngf, Ngf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
spinal cord 2
Ngf (Rattus norvegicus)
Ngf (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 136 100.00 Very High Very High Very High
Nerve growth factor 10 100.00 Very High Very High Very High
Inflammation 4 100.00 Very High Very High Very High
Spinal cord 40 99.36 Very High Very High Very High
Pain 34 98.36 Very High Very High Very High
nMDA receptor 5 96.16 Very High Very High Very High
Stimulus evoked pain 18 92.64 High High
Acute pain 1 68.72 Quite High
cytokine 3 62.56 Quite High
Neuropathic pain 8 57.88 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 100.00 Very High Very High Very High
Pain 53 98.36 Very High Very High Very High
Hypersensitivity 18 92.64 High High
Neuropathic Pain 29 57.88 Quite High
Inflammatory Pain 8 35.80 Quite Low
Nociception 6 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that the increased NGF in response to peripheral inflammation could induce the upregulation of BDNF in the DRG and spinal cord, which subsequently phosphorylated the downstream signals including NMDA receptor subunit NR1, tropomyosine receptor kinase B (TrkB) and extracellular regulating kinase (ERK) [15,16], it is possible that BDNF is also associated with the incision-evoked pain hypersensitivity.
NGF Positive_regulation (induce) of NGF Positive_regulation (upregulation) of BDNF in spinal cord associated with inflammation, nerve growth factor, nmda receptor, hypersensitivity, stimulus evoked pain, bdmf and spinal cord
1) Confidence 0.33 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.67 Pain Relevance 1.99

General Comments

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