INT24069

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Context Info
Confidence 0.14
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.93
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
retinas 4
saphenous nerves 2
stem 2
Hspb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 38 98.96 Very High Very High Very High
substance P 18 96.64 Very High Very High Very High
qutenza 4 93.12 High High
Central nervous system 2 90.52 High High
bradykinin 2 86.88 High High
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 100.00 Very High Very High Very High
Pressure And Volume Under Development 10 99.80 Very High Very High Very High
Cv Unclassified Under Development 36 98.96 Very High Very High Very High
Reperfusion Injury 12 98.60 Very High Very High Very High
Stress 46 95.32 Very High Very High Very High
Apoptosis 20 88.96 High High
Death 36 83.36 Quite High
Targeted Disruption 2 77.48 Quite High
Ganglion Cysts 8 74.72 Quite High
Injury 8 72.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have reported that the electrical translocation of the heat shock protein 27 (Hsp 27) into RGCs reduced the damage of RGCs after ischemia-reperfusion injury in rat retinas (Yokoyama et al 2001).
Negative_regulation (reduced) of Localization (translocation) of heat shock protein 27 in retinas associated with reperfusion injury, ischemia and shock
1) Confidence 0.14 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.63 Pain Relevance 0.18
We have reported that the electrical translocation of the heat shock protein 27 (Hsp 27) into RGCs reduced the damage of RGCs after ischemia-reperfusion injury in rat retinas (Yokoyama et al 2001).
Negative_regulation (reduced) of Localization (translocation) of Hsp 27 in retinas associated with reperfusion injury, ischemia and shock
2) Confidence 0.14 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699777 Disease Relevance 1.63 Pain Relevance 0.18
Simultaneous treatment with stem bromelain and emorfazone decreased significantly the heat-evoked iSP release and edema.
Negative_regulation (decreased) of Localization (release) of heat-evoked iSP in stem associated with pressure and volume under development
3) Confidence 0.11 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2443642 Disease Relevance 0.34 Pain Relevance 0.49
Acute and chronic denervation of the sciatic and saphenous nerves also inhibited the heat-evoked iSP release and edema remarkably.
Negative_regulation (inhibited) of Localization (release) of heat-evoked iSP in saphenous nerves associated with pressure and volume under development
4) Confidence 0.11 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2443642 Disease Relevance 0.33 Pain Relevance 0.47

General Comments

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