INT2407

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Context Info
Confidence 0.62
First Reported 1978
Last Reported 2010
Negated 10
Speculated 3
Reported most in Abstract
Documents 26
Total Number 29
Disease Relevance 5.31
Pain Relevance 10.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GAST) extracellular region (GAST)
Anatomy Link Frequency
plasma 2
capsule 1
colon 1
parietal cell 1
brain 1
GAST (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 40 100.00 Very High Very High Very High
narcan 28 100.00 Very High Very High Very High
Enkephalin 19 100.00 Very High Very High Very High
antagonist 17 100.00 Very High Very High Very High
opiate 13 100.00 Very High Very High Very High
Morphine 10 100.00 Very High Very High Very High
Somatostatin 7 99.92 Very High Very High Very High
tetrodotoxin 3 99.84 Very High Very High Very High
isoflurane 2 99.60 Very High Very High Very High
Dismenorea 7 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxicity 11 99.28 Very High Very High Very High
Ulcers 22 98.44 Very High Very High Very High
Reprotox - General 1 7 98.40 Very High Very High Very High
Duodenal Ulcer 8 98.00 Very High Very High Very High
Pancreatic Cancer 2 96.40 Very High Very High Very High
Disease 17 96.24 Very High Very High Very High
Functional Bowel Disorder 1 95.64 Very High Very High Very High
Hyperplasia 2 94.84 High High
Gallstones 1 94.72 High High
Gallbladder Disease 1 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous naloxone (40 micrograms/kg/hr) significantly inhibited the acid secretory response to sham feeding without affecting the serum gastrin response to sham feeding.
Neg (without) Regulation (affecting) of gastrin associated with narcan
1) Confidence 0.62 Published 1982 Journal Dig. Dis. Sci. Section Abstract Doc Link 7067583 Disease Relevance 0 Pain Relevance 0.47
Naloxone had no effect on serum gastrin concentraitons or on the rate of gastric emptying of the meal.
Neg (no) Regulation (effect) of gastrin associated with narcan
2) Confidence 0.62 Published 1980 Journal Gastroenterology Section Abstract Doc Link 7399233 Disease Relevance 0.09 Pain Relevance 0.98
We investigated the effect of plaunotol on serum gastrin levels after six to eight weeks of omeprazole (20 mg/day) administration in 22 patients (16 males, 6 females; mean age 52.3, range 36-70 years) with peptic ulcer disease.
Spec (investigated) Regulation (effect) of gastrin associated with peptic ulcer disease and disease
3) Confidence 0.61 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7821104 Disease Relevance 0.53 Pain Relevance 0.14
No effect was observed on serum gastrin levels.
Neg (No) Regulation (effect) of gastrin
4) Confidence 0.56 Published 1978 Journal Prostaglandins Section Abstract Doc Link 704919 Disease Relevance 0 Pain Relevance 0.08
Intravenous administration of naloxone (40 micrograms/kg/hr) had no effect on serum gastrin and secretin concentrations or on the gastric acid secretion stimulated by pentagastrin (n = 8).
Neg (no) Regulation (effect) of gastrin associated with narcan
5) Confidence 0.49 Published 1993 Journal Hokkaido Igaku Zasshi Section Abstract Doc Link 8112709 Disease Relevance 0 Pain Relevance 0.80
Effect of oral nalmefene, an opiate-receptor antagonist, on meal-stimulated gastric acid secretion and serum gastrin concentration in man.
Regulation (Effect) of gastrin associated with antagonist and opiate
6) Confidence 0.45 Published 1985 Journal Regul. Pept. Section Title Doc Link 4059587 Disease Relevance 0 Pain Relevance 0.39
Effect of placebo on meal-stimulated gastric acid secretion and serum gastrin concentration.
Regulation (Effect) of gastrin
7) Confidence 0.45 Published 1988 Journal Dig. Dis. Sci. Section Title Doc Link 3338362 Disease Relevance 0.35 Pain Relevance 0.06
Therefore, we evaluated the effect of a placebo capsule on meal-stimulated gastric acid secretion and serum gastrin concentrations in 10 healthy subjects and also in 10 patients with chronic duodenal ulcer.
Regulation (effect) of gastrin in capsule associated with duodenal ulcer
8) Confidence 0.45 Published 1988 Journal Dig. Dis. Sci. Section Abstract Doc Link 3338362 Disease Relevance 0.35 Pain Relevance 0
Excitatory and inhibitory effects of gastrin peptides on gastric motility in sheep.
Regulation (effects) of gastrin
9) Confidence 0.45 Published 1989 Journal Am. J. Physiol. Section Title Doc Link 2569839 Disease Relevance 0 Pain Relevance 0.07
Human stomach and colon were used as positive controls for gastrin and toluidine blue, respectively.
Regulation (controls) of gastrin in colon
10) Confidence 0.45 Published 2001 Journal BJU Int. Section Body Doc Link 11488726 Disease Relevance 0 Pain Relevance 0
Effect of naloxone and morphine on gastric acid secretion and on serum gastrin and pancreatic polypeptide concentrations in humans.
Regulation (Effect) of gastrin associated with narcan and morphine
11) Confidence 0.45 Published 1980 Journal Gastroenterology Section Title Doc Link 7399233 Disease Relevance 0.07 Pain Relevance 1.04
A synthetic met-enkephalin analogue was infused into seven healthy human subjects on a background infusion of pentagastrin to study the effect on gastric acid secretion and serum gastrin concentration.
Regulation (effect) of gastrin associated with enkephalin
12) Confidence 0.45 Published 1981 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 7323691 Disease Relevance 0 Pain Relevance 0.53
The effect of a synthetic met-enkephalin analogue (FK 33-824) on gastric acid secretion and serum gastrin in man.
Regulation (effect) of gastrin associated with enkephalin
13) Confidence 0.45 Published 1981 Journal Scand. J. Gastroenterol. Section Title Doc Link 7323691 Disease Relevance 0 Pain Relevance 0.77
Komarov, in 1938, confirmed the existence of gastrin and its stimulatory effects on acid secretion.
Regulation (effects) of gastrin
14) Confidence 0.45 Published 1990 Journal Surg Gynecol Obstet Section Abstract Doc Link 2152987 Disease Relevance 0.57 Pain Relevance 0.22
There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen.
Neg (no) Regulation (change) of gastrin in plasma associated with somatostatin and cholecystokinin
15) Confidence 0.44 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6147213 Disease Relevance 0 Pain Relevance 0.19
OBJECTIVE: To investigate the effect of different fresh gas flow (FGF) rates on isoflurane pharmacokinetics during anesthesia induction.
Spec (investigate) Regulation (effect) of gas associated with anesthesia and isoflurane
16) Confidence 0.44 Published 2007 Journal Nan Fang Yi Ke Da Xue Xue Bao Section Abstract Doc Link 17666353 Disease Relevance 0 Pain Relevance 0.26
STUDY OBJECTIVE: To determine the effect of different air-O(2) mixtures and fresh gas flows (FGF) on the relationship between the delivered (F(Del)O(2)) and inspired O(2) fraction (FIO(2)) in a circle system.
Spec (determine) Regulation (effect) of gas
17) Confidence 0.44 Published 2001 Journal J Clin Anesth Section Abstract Doc Link 11578893 Disease Relevance 0 Pain Relevance 0
Interestingly, in contrast to the H2-receptor antagonists, which either increase or have no effect on serum gastrin concentrations, enprostil inhibits basal and postprandial gastrin release.
Neg (no) Regulation (effect) of gastrin associated with antagonist
18) Confidence 0.42 Published 1987 Journal Drugs Section Abstract Doc Link 3121276 Disease Relevance 0.78 Pain Relevance 0.31
CCKB-receptors mediate the effects of gastrin on the gut and the effects of CCK in the brain.
Regulation (effects) of gastrin in brain associated with cholecystokinin
19) Confidence 0.38 Published 1993 Journal Acta Gastroenterol. Belg. Section Abstract Doc Link 8266765 Disease Relevance 0.85 Pain Relevance 0.50
Secretin decreased CMR but did not change the D50 for gastrin.
Neg (not) Regulation (change) of gastrin
20) Confidence 0.25 Published 1979 Journal Am. J. Physiol. Section Abstract Doc Link 434148 Disease Relevance 0 Pain Relevance 0.61

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