INT240710

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
neurons 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 21 98.84 Very High Very High Very High
backache 9 94.80 High High
Chronic low back pain 13 93.48 High High
Pain 18 85.52 High High
antagonist 1 77.12 Quite High
ischemia 16 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
Sciatica 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 146 99.40 Very High Very High Very High
INFLAMMATION 26 98.84 Very High Very High Very High
Low Back Pain 23 94.80 High High
Pain 17 85.52 High High
Infection 2 82.08 Quite High
Cv Unclassified Under Development 14 5.00 Very Low Very Low Very Low
Nerve Root Compression 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Acidosis 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither ESR nor hsCRP values were elevated above the normal reference values.
Neg (neither) Positive_regulation (elevated) of Neg (neither) Regulation (values) of ESR
1) Confidence 0.09 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2886244 Disease Relevance 0.60 Pain Relevance 0.43
Because a significant fraction of the [Ca2+]i response to anoxia in DRG neurons appears to be dependent on ER function (see preceding text and discussion) and because the effects of anoxia are mimicked by electron transport inhibition using cyanide, we sought to test for the possible involvement of cADPR in mediating the Ca2+ response to anoxia.
Positive_regulation (dependent) of Spec (appears) Regulation (dependent) of ER in neurons associated with hypoxia
2) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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