INT240711

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.99
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Srsf1) mRNA processing (Srsf1) RNA binding (Srsf1)
nucleus (Srsf1) cytoplasm (Srsf1)
Anatomy Link Frequency
proximal 1
nucleus 1
fibroblasts 1
lung 1
Srsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 5 52.16 Quite High
ischemia 32 5.00 Very Low Very Low Very Low
qutenza 16 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 10 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
isoflurane 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 5 100.00 Very High Very High Very High
Targeted Disruption 5 99.82 Very High Very High Very High
Cancer 35 98.84 Very High Very High Very High
Sarcoma 5 97.92 Very High Very High Very High
Skin Cancer 10 96.04 Very High Very High Very High
Breast Cancer 5 94.08 High High
Colon Cancer 10 93.28 High High
Diabetic Retinopathy 25 88.16 High High
Pathologic Neovascularization 10 84.60 Quite High
Repression 5 60.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of ASF/SF2 in immortalized rodent fibroblasts resulted in formation of high-grade sarcomas after injection into nude mice (43).
Gene_expression (Overexpression) of ASF/SF2 in fibroblasts associated with sarcoma
1) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.97 Pain Relevance 0
Moreover, previously we have shown that ASF/SF2 overexpression preferentially increases usage of the proximal splice site (15) and gives the same effect as IGF-1.
Gene_expression (overexpression) of ASF/SF2 in proximal
2) Confidence 0.67 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
The mean values obtained for Rmin, Rmax, and (Sf2/Sb2) were then used to calibrate measurements of the fluorescence ratio in subsequent experiments using the equation [Ca2+] = (R ?
Gene_expression (/) of Sf2
3) Confidence 0.65 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0 Pain Relevance 0
R) × Sf2/Sb2 × Kd (Grynkiewicz et al. 1985).


Gene_expression (/) of Sf2
4) Confidence 0.65 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0 Pain Relevance 0
Knock-down of ASF/SF2 in lung carcinoma, which has high expression of that molecule, inhibited tumor formation in nude mice (43).
Gene_expression (expression) of ASF/SF2 in lung associated with targeted disruption, lung cancer and cancer
5) Confidence 0.58 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 1.02 Pain Relevance 0
Untreated cells (Fig. 4A) contained both nuclear and cytoplasmic ASF/SF2, whereas after treatment with IGF-1, ASF/SF2 localized specifically to the nucleus (Fig. 4B).
Gene_expression (contained) of ASF/SF2 in nucleus
6) Confidence 0.58 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
Fig. 5A shows that ASF/SF2 was present both in crude nuclear extract and in the pull-down of nuclear extract incubated with an RNA containing the MS2 binding domain RNA fused to an 88-nt fragment containing the initial 35 nucleotides upstream of exon 8a, the coding sequence of exon 8a, and 35 nucleotides of 3?
Gene_expression (present) of ASF/SF2
7) Confidence 0.52 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0

General Comments

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