INT240712

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.38
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
astrocyte 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 22 93.12 High High
ischemia 16 83.92 Quite High
Hippocampus 5 75.84 Quite High
adenocard 1 70.96 Quite High
hyperexcitability 3 33.88 Quite Low
agonist 12 33.24 Quite Low
tetrodotoxin 18 5.00 Very Low Very Low Very Low
Glutamate 18 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Convulsion 49 96.16 Very High Very High Very High
Cv Unclassified Under Development 14 83.92 Quite High
Hypoxia 146 73.88 Quite High
Targeted Disruption 11 65.60 Quite High
Congenital Anomalies 1 37.08 Quite Low
Status Epilepticus 5 31.40 Quite Low
Attention Deficit Hyperactivity Disorder 8 29.68 Quite Low
Acidosis 3 15.36 Low Low
Epilepsy 32 5.00 Very Low Very Low Very Low
Partial Seizures 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
15 min in anoxic aglycemia), profound disturbance of Ca2+ homeostasis with near complete failure of Ca2+ clearance by both SERCA and PMCA and complete depletion of the ER Ca2+ stores.
Negative_regulation (failure) of Negative_regulation (depletion) of Ca2
1) Confidence 0.36 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.22 Pain Relevance 0.04
McClellan et al. [24] reported a large decrease in the level of cMyBP-C phosphorylation when the Ca2+ concentration in the incubation solution for the cardiac trabeculae was reduced from 2.5 mM to 1.25 mM.
Negative_regulation (decrease) of Negative_regulation (reduced) of Ca2
2) Confidence 0.15 Published 2007 Journal Basic Res Cardiol Section Body Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.04
Our finding that the duration of the ictal discharges was significantly reduced upon inhibition of the astrocyte Ca2+ signal by bath perfusion with MPEP or PPADS is consistent with this hypothesis, which needs, however, to be specifically addressed in future experiments.
Negative_regulation (reduced) of Negative_regulation (inhibition) of Ca2 in astrocyte
3) Confidence 0.15 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854117 Disease Relevance 0.16 Pain Relevance 0.11
In contrast, depletion of Ca2+ in the bath solution, which produced gradual depolarization possibly due to inhibition of basal Ca2+ entry and a subsequent reduction of BKCa channel activity, strongly reduced LPI-induced depolarization.
Negative_regulation (reduced) of Negative_regulation (depletion) of Ca2
4) Confidence 0.08 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2931756 Disease Relevance 0 Pain Relevance 0

General Comments

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