INT240714

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.30
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp2b2) cell morphogenesis (Atp2b2) endoplasmic reticulum (Atp2b2)
plasma membrane (Atp2b2) locomotion (Atp2b2) cilium (Atp2b2)
Atp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 64 82.80 Quite High
ASIC 8 47.40 Quite Low
qutenza 32 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 20 5.00 Very Low Very Low Very Low
substance P 12 5.00 Very Low Very Low Very Low
tissue acidosis 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
halothane 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 584 87.76 High High
Cv Unclassified Under Development 56 82.80 Quite High
Nociception 8 37.52 Quite Low
Acidosis 12 14.24 Low Low
Alkalosis 8 5.00 Very Low Very Low Very Low
Coronary Artery Disease 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Exsanguination 4 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
15 min in anoxic aglycemia), profound disturbance of Ca2+ homeostasis with near complete failure of Ca2+ clearance by both SERCA and PMCA and complete depletion of the ER Ca2+ stores.
Negative_regulation (depletion) of Localization (clearance) of PMCA
1) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.22 Pain Relevance 0.04
While this could be due to a direct inhibition of mitochondrial Ca2+ release, it is also possible that it is simply an indirect consequence of reduced cytosolic Ca2+ clearance via PMCA and SERCA.
Negative_regulation (reduced) of Localization (clearance) of PMCA
2) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.37 Pain Relevance 0
Under conditions of anoxic aglycemia, there was a biphasic and more profound elevation of [Ca2+]i, which was associated with complete ER Ca2+ store emptying and progressive, and eventually complete, inhibition of Ca2+ clearance by PMCA and SERCA.
Negative_regulation (inhibition) of Localization (clearance) of PMCA
3) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.49 Pain Relevance 0
15 min in anoxic aglycemia), profound disturbance of Ca2+ homeostasis with near complete failure of Ca2+ clearance by both SERCA and PMCA and complete depletion of the ER Ca2+ stores.
Negative_regulation (failure) of Localization (clearance) of PMCA
4) Confidence 0.09 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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