INT240718

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.57
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Fig4) Golgi apparatus (Fig4) endoplasmic reticulum (Fig4)
Fig4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 31 99.60 Very High Very High Very High
depression 13 98.86 Very High Very High Very High
gABA 14 86.36 High High
Inflammatory stimuli 7 65.36 Quite High
cytokine 7 64.44 Quite High
Inflammation 11 57.68 Quite High
Inflammatory response 1 54.16 Quite High
cOX1 6 50.56 Quite High
cocaine 77 50.00 Quite Low
Migraine 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 292 98.92 Very High Very High Very High
Depression 13 98.86 Very High Very High Very High
INFLAMMATION 22 65.36 Quite High
Affective Disorder 3 60.56 Quite High
Headache 15 50.00 Quite Low
Cv Unclassified Under Development 28 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Acidosis 6 5.00 Very Low Very Low Very Low
Alkalosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figures 13.3b–d show how depression would alter the growth of reward intensity by causing a decrease in gain (Fig. 13.3b), a decrease in sensitivity (Fig. 13.3c) or decreases in both gain and sensitivity (Fig. 13.3d).
Negative_regulation (decrease) of Negative_regulation (decrease) of Fig associated with depression
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994896 Disease Relevance 0.32 Pain Relevance 0.13
The anoxia-induced rise in calcium could also be inhibited by a combination of FCCP plus thapsigargin (100 nM), an irreversible inhibitor of SERCA (n = 4, Fig. 4B), and by FCCP in combination with 25 ?
Negative_regulation (combination) of Negative_regulation (inhibitor) of Fig associated with hypoxia
2) Confidence 0.11 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.54 Pain Relevance 0
The anoxia-induced rise in calcium could also be inhibited by a combination of FCCP plus thapsigargin (100 nM), an irreversible inhibitor of SERCA (n = 4, Fig. 4B), and by FCCP in combination with 25 ?
Negative_regulation (irreversible) of Negative_regulation (inhibitor) of Fig associated with hypoxia
3) Confidence 0.11 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0
The effects of T-DHPG and S-DHPG (Fig. 7) were also abolished by mGluR antagonists.
Negative_regulation (abolished) of Negative_regulation (effects) of Fig associated with antagonist
4) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699468 Disease Relevance 0 Pain Relevance 0.29
M, the sGC inhibitor NS2028 significantly reduced the stimulatory effect of DETA/NO (Fig. 4A).
Negative_regulation (reduced) of Negative_regulation (effect) of Fig
5) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.18 Pain Relevance 0.15

General Comments

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