INT240722

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.79
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ca2) response to stress (Ca2) cytoplasm (Ca2)
cytosol (Ca2) extracellular space (Ca2) hydrolase activity, acting on glycosyl bonds (Cd38)
Anatomy Link Frequency
reticulum 2
Cd38 (Rattus norvegicus)
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 16 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
ASIC 2 5.00 Very Low Very Low Very Low
tissue acidosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 146 97.60 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.16 Very High Very High Very High
Cv Unclassified Under Development 14 5.00 Very Low Very Low Very Low
Acidosis 3 5.00 Very Low Very Low Very Low
Alkalosis 2 5.00 Very Low Very Low Very Low
Coronary Artery Disease 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A model that has been advanced to explain hypoxic pulmonary vasoconstriction suggests that hypoxia-induced increase NADH could stimulate cyclic-ADP-ribose (cADPR) production (Dipp and Evans 2001; Evans and Dipp 2002). cADPR promotes Ca2+ release from the endoplasmic reticulum via ryanodine receptors (Galione 1993; Tanaka and Tashjian 1995; Thorn et al. 1994).
cADPR Positive_regulation (promotes) of Localization (release) of Ca2 in reticulum associated with hypoxia and increased venous pressure under development
1) Confidence 0.04 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.79 Pain Relevance 0

General Comments

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