INT240765

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 12.06
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 5
blood 1
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 178 94.56 High High
Inflammatory response 17 73.04 Quite High
cytokine 13 70.16 Quite High
ischemia 30 68.56 Quite High
chemokine 11 43.12 Quite Low
alcohol 11 35.84 Quite Low
Pain 3 24.16 Low Low
fibrosis 22 5.00 Very Low Very Low Very Low
anesthesia 15 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 827 100.00 Very High Very High Very High
Liver Disease 155 100.00 Very High Very High Very High
Diabetes Mellitus 86 99.78 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 15 98.48 Very High Very High Very High
Cirrhosis 187 96.04 Very High Very High Very High
Cancer 13 94.88 High High
INFLAMMATION 195 94.56 High High
Stress 149 93.36 High High
Diabetes Complications 15 92.84 High High
Anaemia 1 92.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This appears feasible since it is well documented that PON1 activity is profoundly dependent on the lipid and protein compositional environment of the HDL particles [40].
Positive_regulation (dependent) of PON1 associated with disorder of lipid metabolism
1) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.70 Pain Relevance 0
They also showed a profound decrease in serum PON1 activity and an increase in PON1 concentration, together with an increase in total peroxides, MCP-1, and P-III-P concentrations (Table 1).
Positive_regulation (increase) of PON1
2) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.21 Pain Relevance 0
PON1 activity was significantly decreased, and PON1 concentration was significantly increased in the patient group relative to controls.
Positive_regulation (increased) of PON1
3) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.39 Pain Relevance 0
Another possibility is that relatively reduced enzyme activity rather than increased absolute PON1 activity promotes vascular complications.
Positive_regulation (increased) of PON1
4) Confidence 0.66 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.42 Pain Relevance 0
Previous studies from our group [22,23,31] showed that PON1 activity in patients with liver disease is inversely related to PON1 mass.
Positive_regulation (related) of PON1 in liver associated with liver disease
5) Confidence 0.49 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.82 Pain Relevance 0
Interestingly, Liu et al. [54] observed that when they produced recombinant human PON1 in a baculovirus system in Hi5 insect cells, a significant proportion of PON1 was synthesized as a protein of approximately 54,000 Da, and which they identified as a PON1 multimer.
Positive_regulation (proportion) of PON1
6) Confidence 0.49 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.73 Pain Relevance 0
We observed that patients with liver impairment had a significant increase in the HDL phospholipids to apo A-I ratio [1.75 (0.39) vs. 1.10 (0.12); p = 0.007] and in the PON1 mass to apo A-I ratio [227.5 (93.1) vs. 45.0 (10.1); p = 0.002].
Positive_regulation (increase) of PON1 in liver associated with disorder of lipid metabolism
7) Confidence 0.49 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.52 Pain Relevance 0
In previous studies, we reported that serum PON1 activity is decreased in patients with chronic liver impairment, while serum PON1 concentration and hepatic PON1 protein expression are increased [21-23].
Positive_regulation (increased) of PON1 in liver
8) Confidence 0.49 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.18 Pain Relevance 0.12
PON1 activity was significantly decreased, and PON1 concentration was significantly increased in the patient group relative to controls.
Positive_regulation (increased) of PON1
9) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.40 Pain Relevance 0
The HDL particles contained high levels of PON1 that corresponded, in part, to an immunoreactive protein of high molecular weight (55 kDa) not present in control subjects.
Positive_regulation (levels) of PON1 associated with disorder of lipid metabolism
10) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2877049 Disease Relevance 1.02 Pain Relevance 0.07
Bergmeier et al. [44] observed a high PON1 activity in HDL3 particles isolated by ultracentrifugation, and which contained apo E.
Positive_regulation (activity) of PON1
11) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.91 Pain Relevance 0
As stated before, case-control studies showing a decreased serum PON1 activity and increased PON1 concentration have already been published [21-23], and the aim of the present investigation was to add a further insight into the hypothesis that these changes may be related to other HDL compositional alterations.
Positive_regulation (increased) of PON1 associated with disorder of lipid metabolism
12) Confidence 0.45 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.83 Pain Relevance 0.07
With adjustment for blood glucose and diabetes duration, PON1 activity was higher in subjects with different stages of retinopathy versus those without retinopathy.
Positive_regulation (higher) of PON1 in blood associated with diabetes mellitus and ocular toxicity (including many sub-types)
13) Confidence 0.44 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.65 Pain Relevance 0
PON1 activity was higher in the abnormal PFT group but did not achieve statistical significance.
Positive_regulation (higher) of PON1
14) Confidence 0.44 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494642 Disease Relevance 0.78 Pain Relevance 0
To the best of our knowledge, paraoxonase and arylesterase, as known antioxidants, have not been evaluated in patients who underwent LC.
Neg (not) Positive_regulation (evaluated) of paraoxonase
15) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 1.10 Pain Relevance 0
Paraoxonase enzyme shows antioxidant activity by protecting LDL from oxidation and neutralizing free radicals, including hydrogen peroxide.13,27,28 In this study, UD increased the activity of paraoxonase, arylesterase, and liver tissue catalase activity, supporting the protective effect of UD.
Positive_regulation (increased) of paraoxonase in liver
16) Confidence 0.20 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.70 Pain Relevance 0.11
Paraoxonase enzyme shows antioxidant activity by protecting LDL from oxidation and neutralizing free radicals, including hydrogen peroxide.13,27,28 In this study, UD increased the activity of paraoxonase, arylesterase, and liver tissue catalase activity, supporting the protective effect of UD.
Positive_regulation (increased) of arylesterase in liver
17) Confidence 0.17 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020349 Disease Relevance 0.70 Pain Relevance 0.11

General Comments

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