INT24078

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Context Info
Confidence 0.05
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.55
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Thtpa) nucleus (Thtpa) cytoplasm (Thtpa)
Anatomy Link Frequency
dorsal horn 3
spinal cord 1
nodes 1
Thtpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 4 100.00 Very High Very High Very High
adenocard 4 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Deafferentation 1 99.66 Very High Very High Very High
spinal dorsal horn 3 99.62 Very High Very High Very High
substantia gelatinosa 1 99.16 Very High Very High Very High
Pain 11 98.60 Very High Very High Very High
Dorsal horn 5 98.50 Very High Very High Very High
Neuropeptide 3 98.08 Very High Very High Very High
Nerve growth factor 17 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 9 100.00 Very High Very High Very High
Frailty 13 99.60 Very High Very High Very High
Pain 5 98.60 Very High Very High Very High
Hypoxia 1 97.12 Very High Very High Very High
Injury 2 96.72 Very High Very High Very High
Hyperglycemia 1 95.12 Very High Very High Very High
Ulcers 7 94.96 High High
Acid Reflux 4 93.60 High High
Diabetes Mellitus 2 92.72 High High
Peripheral Neuropathy 2 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Resultant decreases in sodium-potassium-adenosine triphosphatase levels ultimately lead to structural alterations at the nodes of Ranvier.
Negative_regulation (decreases) of triphosphatase in nodes associated with adenocard
1) Confidence 0.05 Published 1987 Journal Postgrad Med Section Abstract Doc Link 3306636 Disease Relevance 0.53 Pain Relevance 0.13
OX42 staining with the upper portion of the dorsal horn was found to localize within the areas of deafferentation demonstrated by loss of thiamine monophosphatase activity within the substantia gelatinosa.
Negative_regulation (loss) of thiamine monophosphatase in dorsal horn associated with substantia gelatinosa, dorsal horn and deafferentation
2) Confidence 0.03 Published 1998 Journal Glia Section Abstract Doc Link 9562186 Disease Relevance 0.22 Pain Relevance 0.55
Pantoprazole is a gastric hydrogen-potassium adenosine triphosphatase (H+/K(+)-ATPase) inhibitor.
Negative_regulation (inhibitor) of triphosphatase associated with adenocard
3) Confidence 0.01 Published 2001 Journal Am J Health Syst Pharm Section Abstract Doc Link 11402494 Disease Relevance 0.09 Pain Relevance 0.08
Lansoprazole is a benzimidazole derivative that effectively decreases gastric acid secretion, regardless of the primary stimulus, via inhibition of gastric H+,K(+)-adenosine triphosphatase (ATPase).
Negative_regulation (inhibition) of triphosphatase associated with adenocard
4) Confidence 0.01 Published 1994 Journal Drugs Section Abstract Doc Link 7527761 Disease Relevance 0.48 Pain Relevance 0.08
TDA induced by vinpocetine has been demonstrated to be followed by depletion of the marker enzyme fluoride-resistant acid phosphatase (FRAP) and its isoenzyme thiamine monophosphatase (TMP), and by the decrease in the pain-related neuropeptide substance P from laminae I-II-(III) from the segmentally related, ipsilateral substance of Rolando of the spinal cord.
Negative_regulation (depletion) of thiamine monophosphatase in spinal cord associated with pain, frailty, neuropeptide, spinal cord and substance p
5) Confidence 0.00 Published 2008 Journal Ann. Anat. Section Abstract Doc Link 18413267 Disease Relevance 0.70 Pain Relevance 0.41
Blockade of retrograde transport of NGF results in transganglionic degenerative atrophy (TDA) in the segmentally related ipsilateral superficial spinal dorsal horn, which is characterized by depletion of the marker enzymes fluoride-resistant acid phosphatase (FRAP) and thiamine monophosphatase (TMP).
Negative_regulation (depletion) of thiamine monophosphatase in dorsal horn associated with nerve growth factor, spinal dorsal horn and frailty
6) Confidence 0.00 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17319607 Disease Relevance 0.35 Pain Relevance 0.54
Alteration of gastric acidity in sheep by iv infusion of a H/K-adenosine triphosphatase inhibitor or somatostatin or by intragastric infusion of HCl demonstrated that the CTFP concentrations changed, although to a lesser extent than the changes in circulating gastrin amide.
Negative_regulation (inhibitor) of triphosphatase associated with adenocard and somatostatin
7) Confidence 0.00 Published 2004 Journal Endocrinology Section Abstract Doc Link 15308616 Disease Relevance 0 Pain Relevance 0.10
Blockade of NGF transport is followed by transganglionic degenerative atrophy in the segmentally related, ipsilateral superficial spinal dorsal horn, characterized by depletion of the marker enzymes of nociception, fluoride resistant acid phosphatase (FRAP) and thiamine monophosphatase (TMP) from the Rolando substance and by decrease of the pain-related neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) from lamina I-II-III.
Negative_regulation (depletion) of thiamine monophosphatase in dorsal horn associated with nociception, pain, spinal dorsal horn, calcitonin gene-related peptide, nerve growth factor, neuropeptide, frailty and substance p
8) Confidence 0.00 Published 2010 Journal Ideggyogy Sz Section Abstract Doc Link 20648783 Disease Relevance 0.64 Pain Relevance 0.72
Whenever retrograde transport is impaired (either by injury or by blockade induced by perineural application of microtubule inhibitors) central terminals undergo transganglionic degenerative atrophy (TDA), characterized by depletion of substance P, somatostatin, FRAP (fluoride resistant acid phosphatase), TMPase (thiamine monophosphatase) and lectin-binding fucose-terminated glyco-conjugates.
Negative_regulation (depletion) of thiamine monophosphatase associated with frailty, injury, somatostatin and substance p
9) Confidence 0.00 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 2444067 Disease Relevance 0.54 Pain Relevance 0.21

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