INT240787

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.79
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Bcl2a1c) cellular_component (Bcl2a1c) biological_process (Bcl2a1c)
Anatomy Link Frequency
blood 2
arm 1
carotid artery 1
Bcl2a1c (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 14 55.92 Quite High
cINOD 4 17.88 Low Low
aspirin 60 11.96 Low Low
tolerance 59 5.00 Very Low Very Low Very Low
Bile 26 5.00 Very Low Very Low Very Low
fibrosis 16 5.00 Very Low Very Low Very Low
peripheral neuropathy 14 5.00 Very Low Very Low Very Low
Calcium channel 9 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 142 99.84 Very High Very High Very High
Hyperglycemia 214 99.66 Very High Very High Very High
Diabetes Mellitus 1754 99.62 Very High Very High Very High
Neuropathic Pain 92 99.46 Very High Very High Very High
Albuminuria 82 95.44 Very High Very High Very High
Weight Loss 60 92.76 High High
Body Weight 15 91.56 High High
Cardiovascular Disease 203 86.92 High High
Weight Gain 12 83.60 Quite High
Hypoglycemia 179 80.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With greater A1C variability, there was a greater increase in the mean IMT (r = 0.350, P < 0.001) of the carotid artery.
Positive_regulation (increase) of A1C in carotid artery
1) Confidence 0.22 Published 2010 Journal Korean Diabetes Journal Section Abstract Doc Link PMC2898931 Disease Relevance 0.44 Pain Relevance 0
A meta-analysis of cohort studies showed that every 1% increase in A1C was associated with a 1.17-fold risk of stroke (1).
Positive_regulation (increase) of A1C associated with stroke
2) Confidence 0.11 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2584184 Disease Relevance 1.26 Pain Relevance 0
We have reported a 1.49-fold increased risk of ischemic stroke per 1% increase in A1C in Chinese patients with type 2 diabetes (20).
Positive_regulation (increase) of A1C associated with diabetes mellitus and stroke
3) Confidence 0.11 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2584184 Disease Relevance 1.19 Pain Relevance 0
Colesevelam reduced A1C by 0.32 ± 0.066%, whereas placebo increased A1C by 0.23 ± 0.065%, resulting in a significant LS mean treatment difference of ?
Positive_regulation (increased) of A1C
4) Confidence 0.08 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494667 Disease Relevance 0 Pain Relevance 0
In diabetic Ang2LacZ mice, final blood glucose levels and A1C were also significantly increased (nondiabetic versus diabetic Ang2LacZ: 165.5 ± 26.1 and 582.7 ± 42.5 mg/dl blood glucose, P < 0.001, and 5.4 ± 0.1 and 11.1 ± 1.9% A1C, P < 0.01), and chronic hyperglycemia led to weight loss of 29% in diabetic Ang2LacZ mice (nondiabetic versus diabetic Ang2LacZ: 34.2 ± 3.5 and 24.3 ± 4.5 g, P < 0.05, Table 1).


Positive_regulation (increased) of A1C in blood associated with hyperglycemia, weight loss and diabetes mellitus
5) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2518502 Disease Relevance 1.68 Pain Relevance 0
Analyses of the mean change in A1C from baseline were conducted for two mutually exclusive protocol-defined cohorts: subjects on background sulfonylurea monotherapy and those on background sulfonylurea combination therapy.
Positive_regulation (conducted) of A1C
6) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494667 Disease Relevance 0.16 Pain Relevance 0
The odds of neuropathy increase for each percent increase in A1C; the risk for neuropathy is twice as great for someone with an A1C of 9 versus 6%.
Positive_regulation (increase) of A1C associated with neuropathic pain
7) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518355 Disease Relevance 1.33 Pain Relevance 0.06
An eAG is directly related to A1C and also provides an individual with an estimate of average blood glucose over a period of time, but it uses the same values and units that are observed when using a glucose meter or recording a fasting glucose value on a lab report (5).
Positive_regulation (related) of A1C in blood
8) Confidence 0.04 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797379 Disease Relevance 0.35 Pain Relevance 0
It is clear that postprandial hyperglycemia, like preprandial hyperglycemia, contributes to elevated A1C levels, with its relative contribution being higher at A1C levels that are closer to 7%.
Positive_regulation (elevated) of A1C associated with hyperglycemia
9) Confidence 0.01 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.90 Pain Relevance 0
However, in rapidly evolving diabetes, such as the development of type 1 diabetes in some children, A1C may not be significantly elevated despite frank diabetes.
Neg (not) Positive_regulation (elevated) of A1C associated with diabetes mellitus
10) Confidence 0.01 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797383 Disease Relevance 1.27 Pain Relevance 0
In the setting of an elevated A1C but “nondiabetic” FPG, the likelihood of greater postprandial glucose levels or increased glycation rates for a given degree of hyperglycemia may be present.
Positive_regulation (elevated) of A1C associated with hyperglycemia
11) Confidence 0.01 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797383 Disease Relevance 0.55 Pain Relevance 0
From a baseline median A1C of 8.1%, the intensive arm reached a median A1C of 6.4% within 12 months of randomization, while the standard group reached a median A1C of 7.5%.
Positive_regulation (reached) of A1C in arm
12) Confidence 0.01 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.67 Pain Relevance 0

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