INT24082

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Context Info
Confidence 0.40
First Reported 1981
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.19
Pain Relevance 13.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Sp1) nucleus (Sp1) intracellular (Sp1)
DNA binding (Sp1) transcription factor binding (Sp1) cytoplasm (Sp1)
Anatomy Link Frequency
spinal cord 3
sciatic nerves 2
nipples 2
dorsal 1
reproductive organs 1
Sp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 81 100.00 Very High Very High Very High
qutenza 103 99.98 Very High Very High Very High
fluoxetine 4 99.98 Very High Very High Very High
Sciatic nerve 23 99.92 Very High Very High Very High
Spinal cord 20 99.84 Very High Very High Very High
Dorsal horn 5 99.36 Very High Very High Very High
noradrenaline 3 98.96 Very High Very High Very High
c fibre 1 98.32 Very High Very High Very High
Desipramine 6 96.64 Very High Very High Very High
Somatostatin 8 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.04 Very High Very High Very High
Birth Weight 2 91.04 High High
Pain 4 90.32 High High
Ganglion Cysts 1 80.24 Quite High
Nociception 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radioimmunoassay and immunohistochemistry of nipples from lactating rats treated with capsaicin as neonates revealed a marked depletion of SP-I.
Negative_regulation (depletion) of SP-I in nipples associated with qutenza
1) Confidence 0.40 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083456 Disease Relevance 0.09 Pain Relevance 0.48
The amount of substance P-immunoreactivity (SP-I) was studied in the female rat reproductive organs (uterus, cervix, vagina and ovary) in the diestrous and estrous stages of the estrous cycle, after ovariectomy and on days 7, 14 and 19 of pregnancy.
Negative_regulation (amount) of SP-I in reproductive organs associated with substance p
2) Confidence 0.37 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6207443 Disease Relevance 0 Pain Relevance 0.09
Chronic fluoxetine decreased SP1-binding activity in the two selected brain regions.
Negative_regulation (decreased) of SP1 in brain associated with fluoxetine
3) Confidence 0.35 Published 1998 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 9723120 Disease Relevance 0.44 Pain Relevance 0.88
Immunohistochemistry revealed SP-I nerve trunks and single fibers throughout the nipples of lactating rats.
Negative_regulation (revealed) of SP-I in nipples
4) Confidence 0.34 Published 1984 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6083456 Disease Relevance 0.05 Pain Relevance 0.28
Capsaicin administered intrathecally to rats or mice depleted I-SP in the spinal cord but not in the sciatic nerve.
Negative_regulation (depleted) of I-SP in spinal cord associated with qutenza, sciatic nerve, spinal cord and substance p
5) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.43
Treatment of mice on day 2 caused a similar decrease of the I-SP content in spinal cord and of the capsaicin-evoked I-SP release (88%) as treatment on day 4 or 7 although behavioral changes were different.
Negative_regulation (decrease) of I-SP in spinal cord associated with qutenza, spinal cord and substance p
6) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.39
Neonatal capsaicin treatment of rats resulted in a depletion of I-SP in spinal cord and sciatic nerve for 20 months.
Negative_regulation (depletion) of I-SP in spinal cord associated with qutenza, sciatic nerve, spinal cord and substance p
7) Confidence 0.30 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.24
After local capsaicin application to the sciatic nerve, a decrease of I-SP was found not only in skin and sciatic nerve distal to the site of application, but also in dorsal root ganglia, dorsal roots and the dorsal half of the spinal cord segments L 4-5.
Negative_regulation (decrease) of I-SP in dorsal associated with qutenza, sciatic nerve, spinal cord and substance p
8) Confidence 0.15 Published 1982 Journal Brain Res. Section Abstract Doc Link 6178469 Disease Relevance 0.08 Pain Relevance 1.38
Neonatal capsaicin treatment of rats resulted in a depletion of I-SP in spinal cord and sciatic nerve for 20 months.
Negative_regulation (depletion) of I-SP in sciatic nerve associated with qutenza, sciatic nerve, spinal cord and substance p
9) Confidence 0.10 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6182473 Disease Relevance 0.07 Pain Relevance 1.24
Plasma extravasation by mustard oil was reduced in the skin of the hind paw with a time course identical to the I-SP depletion.
Negative_regulation (depletion) of I-SP in skin associated with substance p
10) Confidence 0.10 Published 1982 Journal Brain Res. Section Abstract Doc Link 6178469 Disease Relevance 0.06 Pain Relevance 1.32
Inhibition of I-SP transport was also found in sciatic nerves of guinea-pig, cat and rabbit.
Negative_regulation (Inhibition) of I-SP in sciatic nerves associated with sciatic nerve and substance p
11) Confidence 0.10 Published 1982 Journal Brain Res. Section Abstract Doc Link 6178469 Disease Relevance 0.09 Pain Relevance 1.25
Treatment with capsaicin depletes the SP-I and decreases the conduction velocity of C-fibers and some Ad2 fibers in the guinea pig heart.
Negative_regulation (depletes) of SP-I in heart associated with c fibre and qutenza
12) Confidence 0.08 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 2444072 Disease Relevance 0.08 Pain Relevance 0.50
Pretreatment of rats with capsaicin (125 mg/kg, s.c.) led to a nearly 40% depletion of I-SP in slices from UDH only.
Negative_regulation (depletion) of I-SP in UDH associated with qutenza, dorsal horn and substance p
13) Confidence 0.03 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6168921 Disease Relevance 0 Pain Relevance 1.66

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