INT240822

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.17
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
G6pc (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 57 96.84 Very High Very High Very High
Inflammatory response 3 50.56 Quite High
Inflammation 34 50.00 Quite Low
cytokine 17 34.00 Quite Low
metalloproteinase 32 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 181 98.80 Very High Very High Very High
Hepatocellular Cancer 2 97.28 Very High Very High Very High
Impaired Glucose Tolerance 53 96.84 Very High Very High Very High
Diabetes Mellitus 54 90.88 High High
Insulin Resistance 115 83.60 Quite High
Weight Gain 5 74.56 Quite High
Body Weight 25 66.28 Quite High
Starvation 2 61.92 Quite High
Hyperinsulinism 14 61.36 Quite High
INFLAMMATION 38 50.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also modestly reduced the expression level of G6Pase, although the effect was not statistically significant.
Negative_regulation (reduced) of Gene_expression (expression) of G6Pase
1) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.26 Pain Relevance 0.06
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Negative_regulation (reduces) of Gene_expression (expression) of G6Pase
2) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.46 Pain Relevance 0.08
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Negative_regulation (downregulation) of Gene_expression (expression) of G6Pase
3) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.45 Pain Relevance 0.08
myel-mice exhibited a 50% reduction in the hepatic expression of a key enzyme of gluconeogenesis, glucose-6-phosphatase (G6Pase), while expression of phosphoenolpyruvate carboxykinase (Pck1) remained unchanged (Figure 2F).
Negative_regulation (reduction) of Gene_expression (expression) of G6Pase
4) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.75 Pain Relevance 0.09
It acts predominantly by suppressing the expression of the genes for the key gluconeogenic enzymes PEPCK and G6Pase [116].
Negative_regulation (suppressing) of Gene_expression (expression) of G6Pase
5) Confidence 0.12 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0

General Comments

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