INT240832

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppargc1a) RNA binding (Ppargc1a) mitochondrion organization (Ppargc1a)
nucleus (Ppargc1a) DNA binding (Ppargc1a) transcription factor binding (Ppargc1a)
Anatomy Link Frequency
skeletal muscle 2
Ppargc1a (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 82 96.64 Very High Very High Very High
fibrosis 10 54.72 Quite High
Acupuncture 10 45.68 Quite Low
tolerance 18 43.32 Quite Low
cytokine 2 34.88 Quite Low
Pain 1 34.32 Quite Low
Fibrositis 1 33.84 Quite Low
Osteoarthritis 1 32.00 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 13 92.52 High High
Congenital Anomalies 2 81.84 Quite High
Coronary Heart Disease 13 79.20 Quite High
Targeted Disruption 2 55.56 Quite High
Fibrosis 10 54.72 Quite High
Hypertrophy 9 52.24 Quite High
Diabetes Mellitus 20 50.00 Quite Low
Obesity 14 50.00 Quite Low
Left Ventricular Hypertrophy 10 50.00 Quite Low
Impaired Glucose Tolerance 13 43.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, to investigate whether ROS induces the phosphorylation of CREB and, hence, results in activation of PGC1?
Regulation (results) of Positive_regulation (activation) of PGC
1) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0
mRNA (2-3-fold), which is similar to the effect of Pioglitazone on the induction of skeletal muscle PGC-1?
Regulation (effect) of Positive_regulation (induction) of PGC-1 in skeletal muscle
2) Confidence 0.22 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0 Pain Relevance 0.24
Furthermore, MEF2 factors have been shown to mediate the Ca2+/Calcineurin activation of PGC-1?
Regulation (mediate) of Positive_regulation (activation) of PGC-1
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794538 Disease Relevance 0.42 Pain Relevance 0.03

General Comments

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