INT240840

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.55
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
Anatomy Link Frequency
F4/80 1
G6pc (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 63 94.04 High High
Inflammatory response 6 50.56 Quite High
Inflammation 68 50.00 Quite Low
metalloproteinase 64 46.40 Quite Low
cytokine 28 34.00 Quite Low
antagonist 14 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 307 97.80 Very High Very High Very High
Hepatocellular Cancer 2 97.28 Very High Very High Very High
Hyperglycemia 12 97.20 Very High Very High Very High
Impaired Glucose Tolerance 56 94.04 High High
Diabetes Mellitus 60 88.20 High High
Insulin Resistance 149 86.60 High High
Weight Gain 6 71.76 Quite High
Body Weight 29 63.48 Quite High
Hyperinsulinism 18 61.36 Quite High
Starvation 3 61.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
reduces hepatic glucose output along with downregulation of PEPCK and G6Pase expression (33).
Gene_expression (expression) of G6Pase
1) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.44 Pain Relevance 0.08
The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).
Gene_expression (expression) of G6Pase
2) Confidence 0.63 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.58 Pain Relevance 0
It also modestly reduced the expression level of G6Pase, although the effect was not statistically significant.
Gene_expression (expression) of G6Pase
3) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.26 Pain Relevance 0.06
myel-mice exhibited a 50% reduction in the hepatic expression of a key enzyme of gluconeogenesis, glucose-6-phosphatase (G6Pase), while expression of phosphoenolpyruvate carboxykinase (Pck1) remained unchanged (Figure 2F).
Gene_expression (expression) of G6Pase
4) Confidence 0.39 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.75 Pain Relevance 0.08
Relative expression of target mRNAs (Adiponectin Mm00456425_m1, Arg1 Mm00475988_m1, Bcl2 Mm00477631_m1, Bax Mm00432050_m1, Ccl2 Mm00441242_m1, Ccl3 Mm00441258, Ccl5 Mm01302428_m1, Cxcl5 Mm00436451_g1, CD11c Mm00498698_m1, CD3 Mm00442746_m1, CD34 Mm00519283_m1, CD4 Mm00442754_m1, CD8 Mm01182108_m1, F4/80 Mm00802530_m1, G6pase Mm839363_m1, Gr-1 Mm00459644_m1, Il1?
Gene_expression (expression) of G6pase in F4/80
5) Confidence 0.35 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.27 Pain Relevance 0
It acts predominantly by suppressing the expression of the genes for the key gluconeogenic enzymes PEPCK and G6Pase [116].
Gene_expression (expression) of G6Pase
6) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.25 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox