INT240842

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2008
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 31
Total Number 33
Disease Relevance 12.00
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) signal transduction (Irs1) plasma membrane (Irs1)
nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
fat 8
skeletal muscle 8
body 2
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 62 99.48 Very High Very High Very High
tolerance 221 93.92 High High
Kinase C 30 87.08 High High
anesthesia 31 60.40 Quite High
Inflammation 30 59.60 Quite High
ketamine 60 57.12 Quite High
Pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 743 100.00 Very High Very High Very High
Targeted Disruption 268 99.88 Very High Very High Very High
Obesity 244 99.48 Very High Very High Very High
Impaired Glucose Tolerance 280 98.72 Very High Very High Very High
Hyperinsulinism 62 87.96 High High
Body Weight 126 85.32 High High
Diabetes Mellitus 218 83.56 Quite High
Dislocations 4 60.96 Quite High
Necrosis 30 60.84 Quite High
Cancer 32 60.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IRS-1 WT associated with targeted disruption
1) Confidence 0.69 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
Ala mice also showed an increased association between IRS-1 and the p85 subunit of PI3-kinase, which reflects increased interaction between IRS-1 and PI 3-kinase likely due to the Ser612?
Positive_regulation (between) of Gene_expression (subunit) of IRS-1
2) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.14 Pain Relevance 0.08
In contrast, there were no differences in insulin-mediated suppression of hepatic glucose production between the Tg IRS-1 Ser?
Positive_regulation (mediated) of Gene_expression (suppression) of IRS-1 Ser
3) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.19 Pain Relevance 0.06
Overexpression of mutated IRS-1 improved glucose metabolism in old mice and Tg IRS-1 Ser?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IRS-1 Ser
4) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.24 Pain Relevance 0.04
Ala mutation of IRS-1 and not on the overexpression of IRS-1 per se, we also generated mice with a similar twofold overexpression of WT IRS-1 (Tg IRS-1 WT) in skeletal muscle as an alternative control.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IRS-1 in skeletal muscle
5) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.40 Pain Relevance 0.04
Overexpression of mutated IRS-1 improved glucose metabolism in old mice and Tg IRS-1 Ser?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IRS-1
6) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.23 Pain Relevance 0.04
We also detected a 20% increase in IRS-1–associated PI3-kinase activity (Fig. 3D) of Tg IRS-1 Ser?
Positive_regulation (associated) of Gene_expression (activity) of IRS-1 Ser
7) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.06 Pain Relevance 0
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IRS-1 associated with targeted disruption
8) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
Overexpression of mutated IRS-1 rescued high-fat diet induced insulin resistance in skeletal muscle.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of IRS-1 in fat associated with insulin resistance
9) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.53 Pain Relevance 0.09
To address this question, we generated IRS-1 Ser302, Ser307, and Ser612 to Ala mutant–overexpression (Tg IRS-1 Ser?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IRS-1 Ser
10) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.61 Pain Relevance 0.12
These findings are consistent with a recent study demonstrating that whole-body IRS-1 overexpressing mice were also not protected from insulin resistance (39).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IRS-1 in body associated with insulin resistance
11) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.71 Pain Relevance 0
Ala mutation of IRS-1 and not on the overexpression of IRS-1 per se, we also generated mice with a similar twofold overexpression of WT IRS-1 (Tg IRS-1 WT) in skeletal muscle as an alternative control.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IRS-1 WT in skeletal muscle
12) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.46 Pain Relevance 0.03
100% overexpression of IRS-1 exclusively in skeletal muscles in transgenic mice compared with their WT littermates (Fig. 1C and D).
Positive_regulation (overexpression) of Gene_expression (overexpression) of IRS-1 in skeletal muscles associated with targeted disruption
13) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.60 Pain Relevance 0
Taken together, these data support the hypothesis that the protection from fat-induced insulin resistance observed in the Tg IRS-1 Ser?
Positive_regulation (induced) of Gene_expression (resistance) of IRS-1 Ser in fat associated with insulin resistance
14) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.76 Pain Relevance 0
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Positive_regulation (generated) of Gene_expression (overexpressing) of IRS-1 WT associated with targeted disruption
15) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
Briefly, we backcrossed Tg IRS-1 Ser?
Positive_regulation (backcrossed) of Gene_expression (backcrossed) of IRS-1 Ser
16) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.23 Pain Relevance 0.08
Ala in a different model, we also generated Tg IRS-1 Ser?
Positive_regulation (generated) of Gene_expression (generated) of IRS-1 Ser
17) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.24 Pain Relevance 0
To analyze the effect of overexpression of mutated IRS-1 in different insulin resistance models, we tested these mice at age 1 year with an IPGTT.
Spec (analyze) Positive_regulation (overexpression) of Spec (analyze) Gene_expression (overexpression) of IRS-1 associated with insulin resistance
18) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.32 Pain Relevance 0.04
Transgenic mice overexpressing WT murine IRS-1 (Tg IRS-1 WT) were generated by the same approach using exactly the same expression vector except for the mutated serine residues.
Positive_regulation (generated) of Gene_expression (overexpressing) of IRS-1 associated with targeted disruption
19) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.33 Pain Relevance 0.07
To address this question, we generated IRS-1 Ser302, Ser307, and Ser612 to Ala mutant–overexpression (Tg IRS-1 Ser?
Positive_regulation (generated) of Gene_expression (overexpression) of IRS-1 Ser
20) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.63 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox