INT240893

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ros1, Irs1) plasma membrane (Ros1, Irs1) cell differentiation (Ros1)
cytoplasm (Irs1) signal transducer activity (Irs1) cytosol (Irs1)
Anatomy Link Frequency
liver 3
Ros1 (Mus musculus)
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 85.12 High High
tolerance 33 27.12 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 63 93.44 High High
Stress 9 61.68 Quite High
Impaired Glucose Tolerance 30 27.12 Quite Low
Diabetes Mellitus 18 5.00 Very Low Very Low Very Low
Body Weight 12 5.00 Very Low Very Low Very Low
Obesity 6 5.00 Very Low Very Low Very Low
Hyperglycemia 6 5.00 Very Low Very Low Very Low
Adenovirus Infection 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Weight Gain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is likely that reduction of ROS increases the phosphorylation and expression of IRS-1 through a reduction of JNK activity.
Negative_regulation (reduction) of ROS Positive_regulation (increases) of Phosphorylation (phosphorylation) of IRS-1
1) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.13 Pain Relevance 0
These findings indicate that the increase of insulin-stimulated tyrosine phosphorylation of IRS-1 by the reduction of ROS in liver of db/db mice is associated with the decreased phosphorylation of IRS-1 at the Ser307 residue.
Negative_regulation (reduction) of ROS in liver Positive_regulation (increase) of Phosphorylation (phosphorylation) of IRS-1 in liver
2) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.06 Pain Relevance 0.04
Interestingly, reduction of ROS increased tyrosine phosphorylation of IRS-1 but decreased tyrosine phosphorylation of IRS-2.
Negative_regulation (reduction) of ROS Positive_regulation (increased) of Phosphorylation (phosphorylation) of IRS-1
3) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.17 Pain Relevance 0

General Comments

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