INT240903

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Mapk8, Ros1) kinase activity (Mapk8, Ros1) cell differentiation (Ros1)
mitochondrion (Mapk8) cytoplasm (Mapk8) cytosol (Mapk8)
Mapk8 (Mus musculus)
Ros1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 16 99.16 Very High Very High Very High
Kinase C 3 96.16 Very High Very High Very High
tolerance 11 6.36 Low Low
fibrosis 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 46 99.32 Very High Very High Very High
INFLAMMATION 15 99.16 Very High Very High Very High
Obesity 13 81.16 Quite High
Metabolic Syndrome 23 76.96 Quite High
Liver Disease 18 75.76 Quite High
Diabetes Mellitus 23 71.28 Quite High
Stress 15 50.00 Quite Low
Repression 2 41.20 Quite Low
Fatty Liver 63 16.96 Low Low
Impaired Glucose Tolerance 11 6.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mechanism of JNK-mediated CREB phosphorylation should be elucidated, JNK at least partly mediates ROS-induced hepatic insulin resistance through the activation of CREB.
JNK Positive_regulation (mediates) of ROS associated with insulin resistance
1) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.18 Pain Relevance 0
Activation JNK and/or p38 kinase especially by saturated FFAs and increased ROS [151, 152] leads to serine phosphorylation and inhibition of insulin receptor substrates IRS-1 and IRS-2, resulting in decreased insulin signaling (i.e., decreased Tyrosine phosphorylation) and increased hepatic gluconeogenesis during insulin resistance.
JNK Positive_regulation (increased) of ROS associated with insulin resistance
2) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.82 Pain Relevance 0.10

General Comments

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