INT240914

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 3.16
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neurons 2
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 92.96 High High
Inflammation 13 89.52 High High
Potency 6 88.64 High High
withdrawal 6 45.80 Quite Low
Hippocampus 6 31.32 Quite Low
tolerance 17 5.00 Very Low Very Low Very Low
Neuritis 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 134 98.32 Very High Very High Very High
Cardiovascular Disease 10 90.60 High High
INFLAMMATION 13 89.52 High High
Cancer 21 88.96 High High
Diabetes Mellitus 48 88.64 High High
Apoptosis 193 88.48 High High
Neurodegenerative Disease 37 86.12 High High
Neuroblastoma 60 73.84 Quite High
Targeted Disruption 40 69.36 Quite High
Disease 29 58.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, our observation of a substantial reduction of Sirt1 identifies this nutrient sensor as a potential mediator of the coordinated downregulation of gluconeogenesis.
Negative_regulation (reduction) of Sirt1
1) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.18 Pain Relevance 0
Conditions of high NADH
                       would lead to partial inactivation of SIRT1, leading to an accumulation
                       of the acetylated form of CYB5R3. 
Spec (partial) Negative_regulation (inactivation) of SIRT1
2) Confidence 0.42 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0 Pain Relevance 0
Sirtinol, a pharmacological inhibitor of SIRT1 with a distinct mechanism of action, also fails to reduce neuroprotection by SIRT1.
Negative_regulation (inhibitor) of SIRT1
3) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.70 Pain Relevance 0.12
Interestingly, the protective effect of SIRT1 in neurons is not reduced by treatments with nicotinamide or sirtinol, two pharmacological inhibitors of SIRT1.
Negative_regulation (inhibitors) of SIRT1 in neurons
4) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605257 Disease Relevance 0.54 Pain Relevance 0
Rather, vaticanol C seemed to inhibit SIRT1 activity in this assay.
Negative_regulation (inhibit) of SIRT1
5) Confidence 0.37 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2882917 Disease Relevance 0.19 Pain Relevance 0.05
Moreover, Sirt1 transcription is inhibited by a NADH-mediated mechanism (41).
Negative_regulation (inhibited) of Sirt1
6) Confidence 0.34 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.29 Pain Relevance 0
Another more selective and potent pharmacological inhibitor of SIRT1 is sirtinol [30], [43]–[45].
Negative_regulation (inhibitor) of SIRT1
7) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.25 Pain Relevance 0.07
It is widely used as a sirtuin inhibitor in cell culture studies and nicotinamide's ability to block SIRT1 activity both in vitro and in cultured cells has previously been established [5], [10], [37], [40]–[42].
Negative_regulation (block) of SIRT1
8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.27 Pain Relevance 0.04
Surprisingly, nicotinamide fails to reduce the neuroprotective activity of SIRT1 in CGNs (Fig. 3A).
Negative_regulation (reduce) of SIRT1
9) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.25 Pain Relevance 0.07
Interestingly, the protective effect of SIRT1 in neurons is not reduced by treatments with nicotinamide or sirtinol, two pharmacological inhibitors of SIRT1.
Neg (not) Negative_regulation (reduced) of SIRT1 in neurons
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2605257 Disease Relevance 0.49 Pain Relevance 0

General Comments

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