INT240934

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 35
Disease Relevance 18.77
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neuronal 4
neurons 2
mammary glands 1
fat 1
liver 1
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 984 99.92 Very High Very High Very High
Inflammation 50 97.56 Very High Very High Very High
agonist 46 97.16 Very High Very High Very High
Acupuncture 120 95.12 Very High Very High Very High
Hippocampus 17 88.04 High High
tolerance 102 86.80 High High
Osteoarthritis 12 80.68 Quite High
Fibrositis 12 79.68 Quite High
Pain 13 79.12 Quite High
Potency 16 77.84 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 461 99.78 Very High Very High Very High
Targeted Disruption 45 99.78 Very High Very High Very High
Alzheimer's Dementia 11 99.76 Very High Very High Very High
Insulin Resistance 337 99.28 Very High Very High Very High
Death 319 99.24 Very High Very High Very High
Diabetes Mellitus 229 99.22 Very High Very High Very High
Stress 137 98.04 Very High Very High Very High
INFLAMMATION 52 97.56 Very High Very High Very High
Disease 145 97.40 Very High Very High Very High
Motor Neuron Diseases 15 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, CR elevates SIRT1 expression in a
                       number of tissues [11], and transgenic mice that overexpress SIRT1
                       exhibit a phenotype mirroring some aspects of CR [12]. 
Gene_expression (expression) of SIRT1 associated with targeted disruption
1) Confidence 0.75 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.46 Pain Relevance 0.03
For example, CR elevates SIRT1 expression in a
                       number of tissues [11], and transgenic mice that overexpress SIRT1
                       exhibit a phenotype mirroring some aspects of CR [12]. 
Gene_expression (overexpress) of SIRT1 associated with targeted disruption
2) Confidence 0.75 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC2837205 Disease Relevance 0.46 Pain Relevance 0.03
EA increased SIRT1 protein expression and upregulated PGC-1?
Gene_expression (expression) of SIRT1 protein associated with electroacupuncture
3) Confidence 0.73 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.02 Pain Relevance 0.60
The effect of EA on SIRT1 gene expression and protein levels was investigated in view of SIRT1's association with metabolic activity and its critical role in insulin sensitivity.
Gene_expression (expression) of SIRT1 associated with electroacupuncture
4) Confidence 0.73 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.15 Pain Relevance 0.46
Collectively, these findings indicate that therapy targeting SIRT1/PGC-1?
Gene_expression (/) of SIRT1
5) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.80 Pain Relevance 0.15
EA significantly increased SIRT1 protein levels in db/db and db/m mice (Figure 2), but it produced no significant effect on SIRT1 mRNA levels (Figure 3(a)).
Gene_expression (levels) of SIRT1 protein associated with electroacupuncture
6) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.14 Pain Relevance 0.43
Collectively, these findings indicate that therapy targeting SIRT1/PGC-1?
Gene_expression (targeting) of SIRT1
7) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.80 Pain Relevance 0.15
Meanwhile, electric stimulation such as exercise induces muscle contraction, which has been observed to activate SIRT1/PGC-1?
Gene_expression (/) of SIRT1 in muscle
8) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.70 Pain Relevance 0.37
The present study tested the hypothesis that electroacupuncture (EA) ameliorates insulin sensitivity via regulation of SIRT1/PGC-1?
Gene_expression (/) of SIRT1 associated with electroacupuncture
9) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.60 Pain Relevance 0.43
Specifically, low-frequency EA improved insulin sensitivity in a mouse model of genetic insulin resistance and diabetes, at least in part, via stimulation of SIRT1/PGC-1?
Gene_expression (/) of SIRT1 associated with diabetes mellitus, insulin resistance and electroacupuncture
10) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.64 Pain Relevance 0.31
Collectively, these studies support the possibility that EA improves insulin sensitivity, at least partially, because of increasing SIRT1/PGC-1?
Gene_expression (/) of SIRT1 associated with electroacupuncture
11) Confidence 0.64 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.15
in neuronal metabolism (St-Pierre et al 2006) and the link between resveratrol, SIRT-1, and PGC-1?
Gene_expression (resveratrol) of SIRT-1 in neuronal
12) Confidence 0.61 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.98 Pain Relevance 0.08
Strikingly, EA likewise induced SIRT1 protein expression, which was concordant with increased PGC-1?
Gene_expression (expression) of SIRT1 protein associated with electroacupuncture
13) Confidence 0.57 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.51 Pain Relevance 0.44
Moreover, overexpression of SIRT1 protects against insulin resistance in diabetic models [7] and high-fat-diet-induced metabolic disorder [8].
Gene_expression (overexpression) of SIRT1 in fat associated with metabolic disorder, diabetes mellitus and insulin resistance
14) Confidence 0.57 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.23 Pain Relevance 0.07
The present study revealed that EA activated SIRT1, indicating that improved insulin resistance by EA may be attributed to enhanced SIRT1 expression.
Gene_expression (expression) of SIRT1 associated with insulin resistance and electroacupuncture
15) Confidence 0.57 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.34 Pain Relevance 0.33
Several investigators have found that the anti-apoptotic effect of SIRT1 overexpression in neurons as well as non-neuronal cell types is mimicked by chemical agonists of SIRT1 and can be inhibited by pharmacological inhibitors of this sirtuin [11], [31]–[36].
Gene_expression (overexpression) of SIRT1 in neurons associated with agonist and apoptosis
16) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.40 Pain Relevance 0.05
Mammals express seven sirtuins, termed SIRT1–SIRT7, which are also referred to as class III histone deacetylases (HDACs).
Gene_expression (express) of SIRT1
17) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.47 Pain Relevance 0.05
For example, the overexpression of SIRT1 prevents neuronal death in tissue culture models of Alzheimer's disease, amyotropic lateral sclerosis, and polyglutamine toxicity and reduces hippocampal degeneration in a mouse model of Alzheimer's disease toxicity [14], [20].
Gene_expression (overexpression) of SIRT1 in neuronal associated with toxicity, disease, motor neuron diseases and death
18) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.76 Pain Relevance 0.05
Finally, the levels of Sirt1, a redox-state sensor that modulates gluconeogenesis through PGC-1?
Gene_expression (levels) of Sirt1
19) Confidence 0.53 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494684 Disease Relevance 0.36 Pain Relevance 0
An interesting and novel finding of our study is that the neuroprotection by SIRT1 is not affected by nicotinamide, a potent and noncompetitive inhibitor of the sirtuins.
Gene_expression (neuroprotection) of SIRT1
20) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.68 Pain Relevance 0.14

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