INT240937

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 13 82.80 Quite High
Central nervous system 3 29.44 Quite Low
antagonist 8 18.60 Low Low
bDMF 6 8.92 Low Low
Bile 39 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammation 17 5.00 Very Low Very Low Very Low
tolerance 9 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 25 74.16 Quite High
Insulin Resistance 13 61.88 Quite High
Obesity 14 60.96 Quite High
Dyslipidemia /

Combined Dyslipidemia

1 50.00 Quite Low
Lipidosis 3 34.56 Quite Low
Repression 5 16.88 Low Low
Glycosuria 1 16.60 Low Low
Polyuria 1 15.96 Low Low
Inflammatory Bowel Disease 32 5.00 Very Low Very Low Very Low
Targeted Disruption 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced CPT-1 mRNA levels in PEPCK-C–silenced animals, together with increased malonyl-CoA content, a potent allosteric inhibitor of CPT-1, provide indirect evidence for a slight inhibition of fatty acid oxidation.
Negative_regulation (Reduced) of Transcription (levels) of PEPCK
1) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.24 Pain Relevance 0
As expected, the fed state was characterized by lower hepatic PEPCK mRNA levels compared to the fasted state (figure 8A) and the central injection of MTII in fasting mice was followed by a strong inhibition of PEPCK mRNA expression, even lower than at the fed state (figure 8A).
Negative_regulation (inhibition) of Transcription (expression) of PEPCK
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.08
, thereby repressing transcription of PEPCK1 and G6P [Miao et al., 2006].
Negative_regulation (repressing) of Transcription (transcription) of PEPCK1
3) Confidence 0.07 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.07 Pain Relevance 0

General Comments

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