INT240995

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Context Info
Confidence 0.21
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.77
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
endothelial cell 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 72.32 Quite High
Neurotransmitter 2 13.36 Low Low
tetrodotoxin 2 10.52 Low Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 164 73.60 Quite High
INFLAMMATION 38 72.32 Quite High
Injury 115 64.68 Quite High
Repression 1 36.08 Quite Low
Retina Disease 2 28.76 Quite Low
Disease 6 25.64 Quite Low
Lymphatic System Cancer 1 16.20 Low Low
Leukemia 1 15.84 Low Low
Diabetic Retinopathy 14 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application with the proteasome inhibitor MG132 or lactacystin, but not the lysosome inhibitor E64, led to significant (P < 0.05) suppression of angiotensin II–induced degradation of synaptophysin (Fig. 4H and I).
Positive_regulation (induced) of Protein_catabolism (degradation) of Fig
1) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.18 Pain Relevance 0
Out of several signaling molecules in the downstream of AT1R, the phosphorylation of ERK, but not Akt or STAT3, was required for synaptophysin degradation (Fig. 5), suggesting that the UPS-dependent synaptophysin degradation is mediated by ERK activation.
Positive_regulation (required) of Protein_catabolism (degradation) of Fig
2) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.06 Pain Relevance 0
However, because HOXA3 has been previously shown to promote angiogenesis and endothelial cell migration, we chose to focus on factors from this gene set that directly promote EPC mobilization and EPC/endothelial cell migration (Fig. 6E).
Positive_regulation (promote) of Protein_catabolism (migration) of Fig in endothelial cell
3) Confidence 0.17 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.53 Pain Relevance 0.09

General Comments

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