INT241019

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mapk1, Hmbs) nucleus (Mapk1, Hmbs) nucleoplasm (Mapk1)
mitochondrion (Mapk1) protein complex (Mapk1) cytosol (Mapk1)
Mapk1 (Mus musculus)
Hmbs (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 3 26.68 Quite Low
tetrodotoxin 1 7.76 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 63 52.80 Quite High
INFLAMMATION 3 26.68 Quite Low
Retina Disease 1 26.00 Quite Low
Disease 3 22.88 Low Low
Diabetic Retinopathy 7 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Out of several signaling molecules in the downstream of AT1R, the phosphorylation of ERK, but not Akt or STAT3, was required for synaptophysin degradation (Fig. 5), suggesting that the UPS-dependent synaptophysin degradation is mediated by ERK activation.
Positive_regulation (activation) of ERK Positive_regulation (mediated) of Protein_catabolism (degradation) of UPS
1) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.05 Pain Relevance 0

General Comments

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