INT241034

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.23
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
cardiomyocytes 2
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 59 98.24 Very High Very High Very High
nMDA receptor 33 95.84 Very High Very High Very High
Glutamate 20 77.52 Quite High
bDMF 3 56.80 Quite High
Action potential 9 5.00 Very Low Very Low Very Low
action potential duration 6 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 76 99.84 Very High Very High Very High
Brain Hemorrhage 38 98.84 Very High Very High Very High
Hypoxia 107 97.72 Very High Very High Very High
Apoptosis 51 86.40 High High
Diabetic Cardiomyopathies 13 71.52 Quite High
Injury 41 59.56 Quite High
Stress 30 54.40 Quite High
Parkinson's Disease 1 50.96 Quite High
Myocardial Infarction 8 49.84 Quite Low
Death 13 48.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated a reduction of Na+/K+ ATPase and increased expression of NCX1 and NR2B in the penumbra by focal cerebral ischemia.
Negative_regulation (reduction) of Gene_expression (expression) of NCX1 associated with brain hemorrhage and ischemia
1) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.48
As shown in Fig. 5, hypoxia-reoxygenated cardiomyocytes pretreated with 50 µM thiopental showed higher levels of SERCA2a (p < 0.05), but the expression of NCX protein decreased (p < 0.05).
Negative_regulation (decreased) of Gene_expression (expression) of NCX protein in cardiomyocytes associated with hypoxia
2) Confidence 0.26 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.54 Pain Relevance 0
Treatment of hypoxia-reoxygenated cells with 50 µM thiopental resulted in up-regulation of mRNA transcription levels of SERCA2a and PMCA1 (p < 0.05), and decreased NCX gene expression (p < 0.01).
Negative_regulation (decreased) of Gene_expression (expression) of NCX gene associated with hypoxia
3) Confidence 0.23 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.61 Pain Relevance 0
Figure 4 shows Western blots of SERCA2a and NCX protein expression.
Negative_regulation (blots) of Gene_expression (expression) of NCX
4) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0

General Comments

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