INT241035

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.89
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
heart 4
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 59 98.24 Very High Very High Very High
nMDA receptor 33 94.60 High High
Glutamate 20 76.28 Quite High
bDMF 3 56.80 Quite High
Action potential 9 5.00 Very Low Very Low Very Low
action potential duration 6 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Hemorrhage 38 98.84 Very High Very High Very High
Hypoxia 107 96.44 Very High Very High Very High
Diabetes Mellitus 76 93.60 High High
Diabetic Cardiomyopathies 13 65.28 Quite High
Myocardial Infarction 8 64.08 Quite High
Injury 41 58.32 Quite High
Stress 30 57.16 Quite High
Parkinson's Disease 1 50.96 Quite High
Death 13 48.16 Quite Low
Apoptosis 51 44.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated a reduction of Na+/K+ ATPase and increased expression of NCX1 and NR2B in the penumbra by focal cerebral ischemia.
Positive_regulation (increased) of Gene_expression (expression) of NCX1 associated with brain hemorrhage and ischemia
1) Confidence 0.41 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.47
Reduced expression of SERCA2a and increased expression of NCX are core changes that contribute to altered Ca2+ homeostasis in the failing heart.37 Reduced expression of SERCA2a and modest, but significantly, increased expression of NCX (reverse mode) in our results would contribute to intracellular Ca2+ overload following hypoxia-reoxygenation.
Positive_regulation (increased) of Gene_expression (expression) of NCX in heart associated with hypoxia
2) Confidence 0.21 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.42 Pain Relevance 0
The rate of decline of the Ca2+ transient is dominated by the rate of Ca2+ uptake by the SR and, to a lesser extent, sarcolemmal Ca2+ extrusion by the Na+/Ca2+ exchanger (NCX), which contributes ?
Positive_regulation (contributes) of Gene_expression (exchanger) of NCX
3) Confidence 0.19 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
Reduced expression of SERCA2a and increased expression of NCX are core changes that contribute to altered Ca2+ homeostasis in the failing heart.37 Reduced expression of SERCA2a and modest, but significantly, increased expression of NCX (reverse mode) in our results would contribute to intracellular Ca2+ overload following hypoxia-reoxygenation.
Positive_regulation (increased) of Gene_expression (expression) of NCX in heart associated with hypoxia
4) Confidence 0.18 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.41 Pain Relevance 0

General Comments

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