INT241036

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Context Info
Confidence 0.22
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.43
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
neuronal 1
cardiomyocytes 1
heart 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 20 98.04 Very High Very High Very High
ischemia 59 89.96 High High
Action potential 18 89.28 High High
nMDA receptor 33 50.00 Quite Low
action potential duration 12 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
bDMF 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 107 99.12 Very High Very High Very High
Bradycardia 2 98.84 Very High Very High Very High
Diabetes Mellitus 152 98.70 Very High Very High Very High
Death 13 94.48 High High
Apoptosis 51 92.32 High High
Diabetic Cardiomyopathies 26 90.44 High High
Cv Unclassified Under Development 19 89.96 High High
Syndrome 2 82.84 Quite High
Cv General 4 Under Development 2 82.40 Quite High
Coronary Heart Disease 6 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a normal brain, NCX1 is thought to be important in buffering neuronal intracellular Ca2+ by transporting one Ca2+ out of cells and three Na+ into the cells (Blaustein & Lederer, 1999).
Regulation (important) of NCX1 in neuronal
1) Confidence 0.22 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.34 Pain Relevance 0.33
Furthermore, thiopental attenuated alterations of genes involving Ca2+ regulation and significantly modulated abnormal changes of NCX and SERCA2a genes in hypoxia-reoxygenated neonatal cardiomyocytes.
Regulation (changes) of NCX in cardiomyocytes associated with hypoxia
2) Confidence 0.12 Published 2010 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2824862 Disease Relevance 0.61 Pain Relevance 0
To confirm functional changes of SERCA2a and NCX, Western blot analyses with anti-SERCA2a and anti-NCX antibodies were performed.
Regulation (changes) of NCX
3) Confidence 0.12 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.57 Pain Relevance 0
Diabetic rats had a decreased heart rate with depressed SR Ca2+-uptake capacity and no detectable change in NCX.
Neg (no) Regulation (change) of NCX in heart associated with diabetes mellitus and bradycardia
4) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 1.13 Pain Relevance 0.04
Diabetic rats had lower levels of SERCA2a expression (P < 0.05), whereas NCX was not significantly altered.
Neg (not) Regulation (altered) of NCX associated with diabetes mellitus
5) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.79 Pain Relevance 0

General Comments

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