INT241104

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Context Info
Confidence 0.66
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 16
Disease Relevance 20.35
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FH) small molecule metabolic process (FH) lyase activity (FH)
cytoplasm (FH)
Anatomy Link Frequency
germline 3
uterine 1
FH (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 6 94.16 High High
imagery 36 80.56 Quite High
Pain 16 55.16 Quite High
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 1128 100.00 Very High Very High Very High
Cancer 676 100.00 Very High Very High Very High
Syndrome 902 99.48 Very High Very High Very High
Disease 512 99.08 Very High Very High Very High
Leiomyosarcoma 50 99.00 Very High Very High Very High
Uterine Fibroids 170 97.68 Very High Very High Very High
Metastasis 64 97.52 Very High Very High Very High
Leiomyomatosis 60 92.16 High High
Rhinitis 10 88.96 High High
Death 32 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurement of FH enzyme activity can be useful in the diagnosis of HLRCC in
Gene_expression (activity) of FH enzyme
1) Confidence 0.66 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.75 Pain Relevance 0
germline mutations in the tumor suppressor gene FH located in 1q42-43 that encodes the
Gene_expression (mutations) of FH in germline associated with cancer
2) Confidence 0.66 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.43 Pain Relevance 0.04
It seems that FH mutation-positive families are in general not highly predisposed to uterine
Gene_expression (mutation) of FH in uterine
3) Confidence 0.66 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.75 Pain Relevance 0
germline mutations in the tumor suppressor gene FH located in 1q42-43 that encodes the
Gene_expression (located) of FH in germline associated with cancer
4) Confidence 0.66 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.41 Pain Relevance 0.04
initial synthesis, the FH proteins are partially imported and
Gene_expression (synthesis) of FH
5) Confidence 0.59 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.09 Pain Relevance 0.03
In mammals, there are two fumarase isoforms

(mitochondrial and cytosolic) that are synthesized from the same mRNA.

Gene_expression (synthesized) of fumarase
6) Confidence 0.58 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 1.20 Pain Relevance 0.03
Measurement of FH enzyme activity can be useful in the diagnosis of HLRCC in
Gene_expression (diagnosis) of HLRCC
7) Confidence 0.58 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.76 Pain Relevance 0
observed between FH mutations and the occurrence of cutaneous
Gene_expression (mutations) of FH
8) Confidence 0.58 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.77 Pain Relevance 0
known to have or suspected of having HLRCC, including individuals with the following:

multiple cutaneous leiomyomas (with at least one

Gene_expression (having) of HLRCC associated with uterine fibroids
9) Confidence 0.58 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.55 Pain Relevance 0
Molecular genetic testing for a germline FH mutation is indicated in all individuals
Gene_expression (mutation) of FH in germline
10) Confidence 0.58 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581790 Disease Relevance 0.47 Pain Relevance 0
develop in HLRCC families are often metastatic at presentation and are a
Gene_expression (families) of HLRCC
11) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.03 Pain Relevance 0.03
alterations in FH lead to HLRCC remains to be determined, but it apparently
Gene_expression (lead) of HLRCC
12) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.45 Pain Relevance 0.05
Even small HLRCC renal tumors are
Gene_expression (tumors) of HLRCC associated with renal cancer
13) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.39 Pain Relevance 0
However, the early experience with HLRCC-associated renal carcinoma suggests
Gene_expression (experience) of HLRCC associated with renal cancer
14) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.76 Pain Relevance 0
This gene encodes fumarate hydratase (FH), an enzyme that is part of the
Gene_expression (encodes) of hydratase
15) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.59 Pain Relevance 0.04
For HLRCC they did not adhere
Neg (not) Gene_expression (adhere) of HLRCC
16) Confidence 0.18 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.97 Pain Relevance 0.06

General Comments

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