INT241115

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 8.36
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) transcription factor binding (Vhl) cytoplasm (Vhl)
Vhl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 85.48 High High
positron emission tomography 44 44.80 Quite Low
palliative 3 38.56 Quite Low
imagery 78 12.00 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Von Hippel-lindau Syndrome 15 100.00 Very High Very High Very High
Renal Cancer 373 99.40 Very High Very High Very High
Cancer 363 99.28 Very High Very High Very High
Hypoxia 6 98.44 Very High Very High Very High
Paraganglioma 16 97.84 Very High Very High Very High
Disease 88 97.28 Very High Very High Very High
Syndrome 148 97.20 Very High Very High Very High
Recurrence 33 96.96 Very High Very High Very High
Carcinoma 25 95.08 Very High Very High Very High
Leiomyomatosis 10 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations in the VHL gene cause elevated protein levels of hypoxia-inducible factor-1?
Regulation (Alterations) of VHL associated with hypoxia
1) Confidence 0.15 Published 2010 Journal Target Oncol Section Body Doc Link PMC2929340 Disease Relevance 1.13 Pain Relevance 0.11
Walther et al.

[27] reported on 52 VHL patients with renal cancer treated at the National

Regulation (reported) of VHL associated with renal cancer and von hippel-lindau syndrome
2) Confidence 0.10 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2522334 Disease Relevance 2.39 Pain Relevance 0
these disorders have been identified by positional cloning including the VHL gene, the MET
Regulation (identified) of VHL
3) Confidence 0.07 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 2.76 Pain Relevance 0
transplantation was an effective form of renal replacement therapy for VHL
Regulation (effective) of VHL
4) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 0.94 Pain Relevance 0
Subsequently it was shown that sporadic ccRCC has biallelic deletion, mutation, or methylation of the VHL gene, and this feature has a major role in the pathogenesis of the disease.16 Loss of the normal VHL gene product in ccRCC results in constitutional high expression of the hypoxia response gene HIF-1?
Regulation (methylation) of VHL associated with hypoxia and disease
5) Confidence 0.04 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 1.15 Pain Relevance 0

General Comments

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