INT241132

Context Info Confidence 0.27 First Reported 2008 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.96 Pain Relevance 0

plasma membrane (Cd79a)

Cd79a (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 24 48.64 Inflammation 35 5.00 rheumatoid arthritis 5 5.00 Chronic pancreatitis 4 5.00 isoflurane 4 5.00 anesthesia 2 5.00 butorphanol 2 5.00 tolerance 2 5.00 Arthritis 2 5.00 ketamine 1 5.00

Disease Link Frequency Relevance Heat Hypergammaglobulinemia 4 99.78 Targeted Disruption 42 98.90 Immunization 28 96.80 Disease 39 96.44 Keratoconjunctivitis 1 94.44 Salivary Gland Disease 20 89.24 Syndrome 77 85.16 Systemic Lupus Erythematosus 11 77.96 Autoimmune Disease 14 71.40 Necrosis 2 60.04

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BAFF Tg mice also had severe hypergammaglobulinemia with high levels of immunoglobulins, specifically IgG, IgM, IgA, and IgE isotypes; however, neither anti-SSA/Ro or anti-SSB/La autoantibodies were detected [79].

Transcription (levels) of IgA associated with targeted disruption and hypergammaglobulinemia

1) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.71 Pain Relevance 0

HBsAg specific IgA and IgG antibodies were detected in BAL samples obtained at the conclusion of the study (23 weeks after initial immunization) from mice immunized intranasally with HBsAg-NE (Figure 5A and B, respectively).

Transcription (detected) of IgA associated with immunization

2) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2496893 Disease Relevance 0.24 Pain Relevance 0

General Comments

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