INT241175

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.34
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Abl2) cellular_component (Abl2) biological_process (Abl2)
Anatomy Link Frequency
neurons 1
Abl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 3 100.00 Very High Very High Very High
long-term potentiation 5 98.76 Very High Very High Very High
nMDA receptor 31 97.96 Very High Very High Very High
Hippocampus 4 82.88 Quite High
Inflammation 7 79.60 Quite High
ischemia 30 75.00 Quite High
Glutamate 2 67.68 Quite High
corticosteroid 35 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 79.60 Quite High
Cv General 4 Under Development 6 75.00 Quite High
Cv Unclassified Under Development 24 64.80 Quite High
Lung Injury 4 50.04 Quite High
Pneumonia 2 48.36 Quite Low
Injury 12 19.44 Low Low
Depression 8 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hypothesis is supported by the elevation of serum NO concentration after 8 hrs of reperfusion when these substances would have been catabolized and NO production follows that observed in groups of IR and l-Arg.
Positive_regulation (groups) of l-Arg
1) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496980 Disease Relevance 0.19 Pain Relevance 0.07
However, similar to genes in Class 1 (ASS and MDH), we observed a lack of tolerance in arginase (ARG) and GDH.
Positive_regulation (tolerance) of ARG associated with tolerance
2) Confidence 0.09 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.08
After 1 hr of reperfusion serum NO concentration was elevated in IR1 and l-Arg(IR1) groups compared with group C but not in l-NAME(IR1) and Allo(IR1) group.
Neg (not) Positive_regulation (elevated) of l-Arg
3) Confidence 0.08 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2496980 Disease Relevance 0.14 Pain Relevance 0.07
In cortical neurons, Abl and Arg are required for normal dendritic branching and are activated downstream of integrin receptors [17,20].
Positive_regulation (activated) of Arg in neurons
4) Confidence 0.06 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0 Pain Relevance 0.33

General Comments

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