INT241191

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.28
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Kctd1) transcription factor binding (Kctd1)
Kctd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 7 83.16 Quite High
depression 2 69.72 Quite High
antagonist 6 53.12 Quite High
Thalamus 2 50.12 Quite High
cva 4 45.04 Quite Low
nMDA receptor 2 40.64 Quite Low
imagery 10 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 159 100.00 Very High Very High Very High
Vascular Dementia 130 100.00 Very High Very High Very High
Obesity 13 99.60 Very High Very High Very High
Overweight 1 99.50 Very High Very High Very High
Stroke 61 98.60 Very High Very High Very High
Alzheimer's Dementia 17 98.60 Very High Very High Very High
Genetic Predisposition To Disease 2 96.80 Very High Very High Very High
Dementia 217 92.40 High High
Death 4 83.28 Quite High
Hypertension 29 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, three of the acetylcholinesterase inhibitors approved for use in AD: donepezil, rivastigmine, and galantamine have also been used in VaD.
Positive_regulation (used) of VaD associated with vascular dementia and disease
1) Confidence 0.06 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695177 Disease Relevance 0.96 Pain Relevance 0.10
Both incidence and prevalence of VaD increase with age and tend to be higher in men (Zhang 1990; Hofman et al 1991; Ruitenburg et al 2001).
Positive_regulation (increase) of VaD associated with vascular dementia
2) Confidence 0.06 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695177 Disease Relevance 1.59 Pain Relevance 0.06
More recently a 36-year longitudinal study of a large cohort (n = 10,136) found that people who were obese at midlife (BMI >30) had a 3.10-fold increased risk of AD (HR = 3.10; 95% CI = 2.19–4.38) and a 5-fold increased in risk of Vad (HR = 5.01; 95% CI = 2.98–8.43), while those who were overweight (BMI > 25) had a 2-fold increased risk of AD and Vad (HR =2.09; 95% CI = 1.69–2.60 for Alzheimer disease and HR = 1.95; 95% CI = 1.29–2.96 for vascular dementia), independent of vascular comorbidities (Whitmer 2007).
Positive_regulation (increased) of Vad associated with vascular dementia, alzheimer's dementia, obesity, disease and overweight
3) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496986 Disease Relevance 1.73 Pain Relevance 0

General Comments

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