INT241211

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
B12 1
CIMT (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 20 50.00 Quite Low
Angina 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 53 98.66 Very High Very High Very High
Stroke 124 98.20 Very High Very High Very High
Atherosclerosis 93 90.84 High High
Hyperlipidemia 30 89.84 High High
Diabetes Mellitus 48 83.52 Quite High
Hypertension 11 74.12 Quite High
Increased Venous Pressure Under Development 44 72.60 Quite High
Death 29 71.40 Quite High
Cardiovascular Disease 57 70.80 Quite High
Disorder Of Lipid Metabolism 59 69.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
= 0.05) to detect a reduction in mean CIMT of 0.07 mm and an absolute increase in FMD of 1.6%.


Negative_regulation (reduction) of CIMT
1) Confidence 0.37 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.05 Pain Relevance 0
We found that long-term homocysteine-lowering with folic acid, vitamin B6 and vitamin B12 did not reduce CIMT or increase FMD in individuals with a history of stroke.
Neg (not) Negative_regulation (reduce) of CIMT in B12 associated with stroke
2) Confidence 0.28 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.51 Pain Relevance 0
The pooled estimate from these studies was a significant reduction in CIMT of 0.13 mm (95%CI -0.25, -0.01 mm, n = 606, p = 0.03, I2 = 84.1%) in vitamin-treated subjects compared with placebo (Figure 3).
Negative_regulation (reduction) of CIMT
3) Confidence 0.28 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.09 Pain Relevance 0
Our results indicate that long-term homocysteine-lowering treatment with B-vitamins does not significantly reduce CIMT or increase FMD in people with a history of stroke.
Neg (not) Negative_regulation (reduce) of CIMT associated with stroke
4) Confidence 0.28 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.32 Pain Relevance 0
However, as tHcy is positively associated with CIMT and negatively with FMD, any baseline differences in these measurements between the groups should have increased rather than reduced the probability of finding improved FMD and CIMT in the vitamin group at follow-up.
Negative_regulation (improved) of CIMT
5) Confidence 0.27 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2559819 Disease Relevance 0.17 Pain Relevance 0
mg of Ezetimibe in 720 patients with familial hypercholesterolemia revealed that combination therapy did not result in a significant reduction in CIMT after 24 months of therapy (Simvastatin only: 0.0058??
Negative_regulation (reduction) of CIMT associated with hyperlipoproteinemia type ii
6) Confidence 0.21 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2909714 Disease Relevance 0.69 Pain Relevance 0
Although this trial showed no benefit in reducing CIMT by the combination of simvastatin and ezetimibe, it did show the expected lowering of LDL-C and apoB levels.
Negative_regulation (reducing) of CIMT
7) Confidence 0.13 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.20 Pain Relevance 0
The ARBITER study similarly showed a reduction in CIMT by 0.034 mm with atorvastatin 80 mg vs 0.025 mm with pravastatin 40 mg after 12 months (p = 0.03) (Taylor et al 2002).
Negative_regulation (reduction) of CIMT
8) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496987 Disease Relevance 0.65 Pain Relevance 0

General Comments

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