INT24122

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 5.33
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ltf) extracellular region (Ltf) molecular_function (Ltf)
cellular_component (Ltf) biological_process (Ltf) cytoplasm (Ltf)
Anatomy Link Frequency
exocrine pancreas 1
spinal cord 1
bowel 1
phrenic 1
upper 1
Ltf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 4 100.00 Very High Very High Very High
primary afferent fibers 4 99.58 Very High Very High Very High
Inflammation 6 98.76 Very High Very High Very High
Chronic pancreatitis 5 95.40 Very High Very High Very High
Pain 1 95.36 Very High Very High Very High
spastic colon 1 93.84 High High
spinal dorsal horn 4 91.88 High High
wide dynamic range 4 90.52 High High
Sciatic nerve 2 90.40 High High
c fibre 8 89.08 High High
Disease Link Frequency Relevance Heat
Hypoxia 18 100.00 Very High Very High Very High
Gastrointestinal Disease 2 99.98 Very High Very High Very High
INFLAMMATION 3 98.76 Very High Very High Very High
Inflammatory Bowel Disease 6 98.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 5 97.80 Very High Very High Very High
Aids-related Complex 10 96.96 Very High Very High Very High
Pancreatitis 9 96.92 Very High Very High Very High
Nociception 4 96.72 Very High Very High Very High
Salivary Gland Disease 1 96.16 Very High Very High Very High
Diarrhoea 1 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cats, vagotomy increases LTF of upper airway muscles but may decrease LTF of accessory pump muscles.
Positive_regulation (increases) of LTF in upper
1) Confidence 0.61 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18652877 Disease Relevance 0.14 Pain Relevance 0
In gastrointestinal diseases increased fecal lactoferrin is a sensitive and specific surrogate marker for inflammatory bowel diseases in patients with chronic diarrhea and pain, and ascites lactoferrin can also provide a promising and reliable biomarker for bacterial peritonitis.
Positive_regulation (increased) of lactoferrin in bowel associated with pain, pressure and volume under development, diarrhoea, gastrointestinal disease, inflammation and peritonitis
2) Confidence 0.45 Published 2009 Journal Intern. Med. Section Abstract Doc Link 19652425 Disease Relevance 0.87 Pain Relevance 0.19
It remains an open question whether the lactoferrin increase is only an unspecific reaction in inflammation or is something specific for pancreatitis.
Spec (whether) Positive_regulation (increase) of lactoferrin associated with inflammation and pancreatitis
3) Confidence 0.45 Published 1987 Journal Digestion Section Abstract Doc Link 2445612 Disease Relevance 0.78 Pain Relevance 0.12
In propofol-anesthetized rats no significant changes of PNA were recorded after the last hypoxic episode, i.e. no pLTF was induced.
Positive_regulation (induced) of pLTF associated with hypoxia
4) Confidence 0.45 Published 2010 Journal Respir Physiol Neurobiol Section Abstract Doc Link 20038457 Disease Relevance 0.71 Pain Relevance 0.15
Although 100 Hz CS of primary afferent fibers is commonly used to induce spinal cord LTF, this frequency exceeds the physiological firing range.
Positive_regulation (induce) of LTF in spinal cord associated with primary afferent fibers and spinal cord
5) Confidence 0.44 Published 2008 Journal Neuroscience Section Abstract Doc Link 18555615 Disease Relevance 0.25 Pain Relevance 0.62
The magnitude of hypoglossal LTF increased after vagotomy (vagi intact, -5+/-10%; vagotomy, 66+/-11% above baseline; p<0.05); whereas, the magnitude of phrenic LTF decreased after vagotomy (vagi intact, 135+/-24%; vagotomy, 40+/-13% above baseline; p<0.05).
Positive_regulation (increased) of LTF in phrenic
6) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18652877 Disease Relevance 0.15 Pain Relevance 0
The pLTF, elicited by AIH, was induced in the urethane-anesthetized rats.
Positive_regulation (induced) of pLTF associated with hypoxia
7) Confidence 0.39 Published 2010 Journal Respir Physiol Neurobiol Section Abstract Doc Link 20038457 Disease Relevance 0.67 Pain Relevance 0.13
Increased lactoferrin levels could result in part from the activity and degranulation of polymorphonuclear leukocytes.
Positive_regulation (Increased) of lactoferrin in polymorphonuclear leukocytes
8) Confidence 0.36 Published 1985 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 3859912 Disease Relevance 0.47 Pain Relevance 0.25
Three hertz stimulation induced the early phase of LTF, but the responses were decremental.
Positive_regulation (induced) of LTF
9) Confidence 0.32 Published 2008 Journal Neuroscience Section Abstract Doc Link 18555615 Disease Relevance 0.41 Pain Relevance 0.56
It is concluded that the alterations leading to an elevation of albumin and lactoferrin and a fall in other secretory values are restricted to the exocrine pancreas and do not affect salivary glands in chronic pancreatitis.
Positive_regulation (elevation) of lactoferrin in exocrine pancreas associated with salivary gland disease and chronic pancreatitis
10) Confidence 0.17 Published 1982 Journal Digestion Section Abstract Doc Link 7128960 Disease Relevance 0.34 Pain Relevance 0.25
Sera of these patients were also tested for anti-alpha granules, anti-myeloperoxidase, and anti-lactoferrin activities.
Positive_regulation (tested) of anti-lactoferrin
11) Confidence 0.01 Published 1993 Journal Am. J. Gastroenterol. Section Abstract Doc Link 8503382 Disease Relevance 0.53 Pain Relevance 0.17

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