INT241236

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 1.82
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Anatomy Link Frequency
HL-60 2
kidney 2
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 4 98.24 Very High Very High Very High
antagonist 3 97.88 Very High Very High Very High
TRP channel 17 93.04 High High
Thermal hyperalgesia 2 57.60 Quite High
Inflammation 4 56.44 Quite High
Calcium channel 2 26.48 Quite Low
Angina 1 12.16 Low Low
imagery 86 5.00 Very Low Very Low Very Low
ketamine 13 5.00 Very Low Very Low Very Low
Cholecystokinin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 26 99.84 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 113 99.36 Very High Very High Very High
Renal Failure 3 98.00 Very High Very High Very High
Disease 36 97.88 Very High Very High Very High
Cyst 31 93.44 High High
Stress 18 87.44 High High
Congenital Anomalies 10 87.08 High High
Repression 18 69.68 Quite High
Coronary Heart Disease 4 63.96 Quite High
Left Ventricular Hypertrophy 15 61.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is tempting to speculate that TRPP2 utilizes TRPV4 to mediate mechano- and osmosensory signals required for TRPP2 functions such as systemic osmotic and blood pressure regulation that are impaired in polycystic kidney disease before the onset of renal failure.
Negative_regulation (impaired) of TRPP2 in kidney associated with renal failure and polycystic kidney disease
1) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.36 Pain Relevance 0.16
mice; however, the additional loss of one TRPP2 allele (transheterozygous animals) drastically augmented the thermosensory defect at 44°C and 46°C, exceeding the latencies for either TRPV4?
Negative_regulation (loss) of TRPP2
2) Confidence 0.43 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.25 Pain Relevance 0.09
Therefore we sought to specifically down-regulate PKD1 and PKD2 in differentiated HL-60 cells to the levels observed in undifferentiated cells.
Negative_regulation (regulate) of PKD2 in HL-60
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
Down-regulation of PKD1 and PKD2 was achieved with siRNA oligonucleotides targeting PKD1 (5?
Negative_regulation (regulation) of PKD2
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
Therefore, to test the effect of specific down-regulation of PKD1 or PKD2 on the extracellular killing of C. neoformans by differentiated HL-60, down-regulated cells were incubated with C. neoformans for 4 h in a 20?
Negative_regulation (regulation) of PKD2 in HL-60
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
Down-regulation of PKD1 and PKD2
Negative_regulation (regulation) of PKD2
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
Down-regulation of PKD1 and PKD2 was achieved by nucleofecting cells with 4.5 µg siRNA as described for SMS.
Negative_regulation (regulation) of PKD2
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
An antagonist with high potency and selectivity for the human VPV2R (tolvaptan) has also been shown to be an effective treatment in PKD2 mouse model of autosomal dominant polycystic kidney disease [91].
Negative_regulation (treatment) of PKD2 in kidney associated with antagonist, autosomal dominant polycystic kidney, disease and potency
8) Confidence 0.14 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.03 Pain Relevance 0.14
While compounds 3 and 5 are structurally very close to PC1 and PC2, compound 4 is a guanine analog (Figure 3A).
Negative_regulation (close) of PC2
9) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.07 Pain Relevance 0
The absence of PC2 antibiotic activity is consistent with the ?
Negative_regulation (absence) of PC2
10) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.11 Pain Relevance 0
When cells were grown in minimal medium with increasing concentrations of PC1 and PC2, beta-galactosidase activity was clearly repressed in a dose-dependent manner suggesting a modulation of the guanine riboswitch gene regulation by both molecules.
Negative_regulation (repressed) of PC2
11) Confidence 0.03 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0 Pain Relevance 0

General Comments

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