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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.44
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Anatomy Link Frequency
cilium 1
ciliary 1
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanotransduction 2 97.80 Very High Very High Very High
TRP channel 8 72.92 Quite High
Mechanosensation 10 71.72 Quite High
metalloproteinase 1 66.08 Quite High
Cholecystokinin 1 44.32 Quite Low
imagery 19 23.36 Low Low
Somatostatin 8 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Kidney Disease 131 99.14 Very High Very High Very High
Bartter Syndrome 2 97.96 Very High Very High Very High
Stress 11 89.92 High High
Cancer 2 89.08 High High
Renal Failure 3 85.92 High High
Disease 62 85.08 High High
Apoptosis 34 79.24 Quite High
Cyst 67 72.16 Quite High
Reprotox - General 1 1 63.52 Quite High
Hyperplasia 2 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although both channels localize to the cilium of tubular epithelial cells and are required for flow-induced Ca2+ signals, the lack of renal cysts in TRPV4-deficient animals indicates that activation of the ciliary polycystin-1–TRPP2 complex by a mechanism other than flow-induced deflection of the cilium might be critical for the regulation of tubular morphology.

Positive_regulation (activation) of TRPP2 in cilium associated with polycystic kidney disease
1) Confidence 0.46 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.36 Pain Relevance 0.12
Stimulation of polycystin-2-mediated Ca2+release.
Positive_regulation (Stimulation) of polycystin-2-mediated
2) Confidence 0.43 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.74 Pain Relevance 0
More specifically, ciliary polycystin-1 and polycystin-2 function together with ryanodine receptors to mediate mechanotransduction into the intracellular Ca2+ signaling response (Fig. 3).
Positive_regulation (ciliary) of polycystin-2 in ciliary associated with mechanotransduction
3) Confidence 0.14 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.10 Pain Relevance 0.08
Differently from PKD1 or PKD2, PKD3 level did not increase during differentiation, suggesting that its activity is not regulated during differentiation as PKD1 or PKD2.
Positive_regulation (increase) of PKD2
4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.23 Pain Relevance 0.03
When cells were grown in minimal medium with increasing concentrations of PC1 and PC2, beta-galactosidase activity was clearly repressed in a dose-dependent manner suggesting a modulation of the guanine riboswitch gene regulation by both molecules.
Positive_regulation (increasing) of PC2
5) Confidence 0.06 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0 Pain Relevance 0

General Comments

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