INT241239

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.55
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 8 44.72 Quite Low
metalloproteinase 3 42.64 Quite Low
Cholecystokinin 3 20.88 Low Low
imagery 35 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Mechanosensation 2 5.00 Very Low Very Low Very Low
tail-flick 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 7 97.28 Very High Very High Very High
Fungal Infection 57 81.04 Quite High
Reprotox - General 1 3 40.08 Quite Low
Hypoxia 3 34.16 Quite Low
Pancreatic Cancer 3 31.12 Quite Low
Neuroendocrine Cancer 3 26.00 Quite Low
Infection 99 7.36 Low Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Candida Infection 15 5.00 Very Low Very Low Very Low
Cryptococcus Infection 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address the question of whether the TRPP2 effect on swelling-activated currents is simply mediated through increased surface expression of TRPV4, we inserted a V5 tag into the first extracellular loop of TRPV4 and TRPP2, respectively, and monitored either ion channel at the cell surface using a modified ELISA system (Wegierski et al., 2006).
Regulation (loop) of TRPP2 associated with pressure and volume under development
1) Confidence 0.27 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.35 Pain Relevance 0
It was found that only down-regulation of PKD1 and not PKD2 inhibited the killing of C. neoformans cells.
Regulation (regulation) of PKD2
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.08 Pain Relevance 0
Down-regulation of PKD1 and PKD2 was achieved by nucleofecting cells with 4.5 µg siRNA as described for SMS.
Regulation (regulation) of PKD2
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0
In addition siRNA targeting PKD1, but not that targeting PKD2, inhibited the killing of C. neoformans (Figure 5C), supporting an isoform-specific function.
Regulation (targeting) of PKD2
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0.12 Pain Relevance 0

General Comments

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