INT241240

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 12.20
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pkd1) plasma membrane (Pkd1) nucleus (Pkd1)
cilium (Pkd1)
Anatomy Link Frequency
cilia 1
tail 1
epithelial cells 1
MDCK 1
kidney 1
Pkd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Mechanosensation 56 99.00 Very High Very High Very High
TRP channel 17 97.56 Very High Very High Very High
Mechanotransduction 13 66.44 Quite High
fibrosis 28 31.16 Quite Low
Kinase C 13 16.04 Low Low
imagery 70 5.00 Very Low Very Low Very Low
Somatostatin 52 5.00 Very Low Very Low Very Low
antagonist 16 5.00 Very Low Very Low Very Low
abdominal pain 13 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 69 100.00 Very High Very High Very High
Targeted Disruption 78 99.84 Very High Very High Very High
Disease 445 99.76 Very High Very High Very High
Autosomal Dominant Polycystic Kidney 127 99.50 Very High Very High Very High
Adhesions 247 99.28 Very High Very High Very High
Polycystic Kidney Disease 838 98.60 Very High Very High Very High
Cyst 451 98.44 Very High Very High Very High
Tuberous Sclerosis 24 97.12 Very High Very High Very High
Cystic Kidney Diseases 107 96.72 Very High Very High Very High
Stress 38 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This selective growth inhibition can be explained by PC1/PC2 inhibiting the biosynthesis or transport of essential metabolites, which are present in CAMHB but not in minimal medium.
Gene_expression (explained) of PC1
1) Confidence 0.54 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858708 Disease Relevance 0.07 Pain Relevance 0
Studies using in vitro models of tubulogenesis and cystogenesis based on MDCK cells demonstrated that expression of polycystin-1 at cell-cell junctions at controlled levels is critical for proper tubular differentiation [65].
Gene_expression (expression) of polycystin-1 in MDCK
2) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.70 Pain Relevance 0
Further analysis has shown that polycystin-1 expression inhibits Cdk2 and induces p21waf1.
Gene_expression (expression) of polycystin-1
3) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.09 Pain Relevance 0
In addition, lowering of Pkd1 expression is sufficient to cause PKD in mice [28].
Gene_expression (expression) of Pkd1
4) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.81 Pain Relevance 0
In addition, polycystin-1 is highly expressed during development, with significant down-regulation of its expression in adult tissues.
Gene_expression (expressed) of polycystin-1
5) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.60 Pain Relevance 0
The overlapping expression and localization patterns of polycystin-1 and -2 support their role as a complex in regulating multiple processes in tubular epithelia [62].
Gene_expression (expression) of polycystin-1
6) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.19 Pain Relevance 0
Activated Wnt signaling was initially implicated in PKD through studies demonstrating that overexpression of the cytoplasmic tail of polycystin-1 stabilizes endogenous beta-catenin and stimulates TCF-dependent gene transcription in vitro [90].
Gene_expression (overexpression) of polycystin-1 in tail
7) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.51 Pain Relevance 0
Polycystin-1 (PC-1), polycystin-2 (PC-2) and other cystoproteins (not shown) are expressed in primary cilia, basal bodies or centrosomes.
Gene_expression (expressed) of Polycystin-1 in cilia
8) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.28 Pain Relevance 0.13
It is possible that reduced expression of the normal PKD1 allele below a critical level due to genetic or environmental factors may lead to cyst formation in the kidneys of ADPKD patients [28].
Gene_expression (expression) of PKD1 associated with polycystic kidney disease and cyst
9) Confidence 0.47 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.86 Pain Relevance 0
Both polycystin-1 and polycystin-2 are present in the primary cilium of tubular epithelial cells [20].
Gene_expression (present) of polycystin-1 in epithelial cells
10) Confidence 0.44 Published 2011 Journal International Journal of Nephrology Section Body Doc Link PMC3017903 Disease Relevance 1.17 Pain Relevance 0.05
Major genes for TSC and autosomal dominant polycystic kidney disease (PKD), TSC2 and PKD1, respectively, lie adjacent to each other at chromosome 16p3.3, suggesting a role for PKD1 in the etiology of renal cystic disease in TSC.
Gene_expression (respectively) of PKD1 in kidney associated with autosomal dominant polycystic kidney and disease
11) Confidence 0.42 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.62 Pain Relevance 0
Patients with contiguous PKD1-TSC2 gene syndrome develop a severe PKD.
Gene_expression (syndrome) of PKD1 associated with syndrome
12) Confidence 0.40 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.51 Pain Relevance 0
These data suggest that abnormal levels of polycystin-1 expression can trigger pathogenic mechanisms leading to cyst formation.
Gene_expression (expression) of polycystin-1 associated with cyst
13) Confidence 0.36 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.04 Pain Relevance 0
On the other hand, over-expression of polycystin-1 in transgenic animals also results in cyst formation [29, 30].
Gene_expression (expression) of polycystin-1 associated with targeted disruption and cyst
14) Confidence 0.36 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.98 Pain Relevance 0
On the other hand, over-expression of polycystin-1 in transgenic animals also results in cyst formation [29, 30].
Gene_expression (over) of polycystin-1 associated with targeted disruption and cyst
15) Confidence 0.36 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.98 Pain Relevance 0
On the other hand, over-expression of polycystin-1 in transgenic animals also results in cyst formation [29, 30].
Gene_expression (-) of polycystin-1 associated with targeted disruption and cyst
16) Confidence 0.36 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.98 Pain Relevance 0
TRPP2, a member of the transient receptor potential (TRP) family of ion channels, assembles with the PKD1 gene product polycystin-1, a large integral membrane protein with distant homology to TRP channels, to form a receptor–ion channel complex (Hanaoka et al., 2000; Köttgen, 2007).
Gene_expression (product) of PKD1 associated with trp channel
17) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.39 Pain Relevance 0.05
TRPP2, a member of the transient receptor potential (TRP) family of ion channels, assembles with the PKD1 gene product polycystin-1, a large integral membrane protein with distant homology to TRP channels, to form a receptor–ion channel complex (Hanaoka et al., 2000; Köttgen, 2007).
Gene_expression (product) of polycystin-1 associated with trp channel
18) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.40 Pain Relevance 0.05

General Comments

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