INT241241

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Pkd2) transport (Pkd2) endoplasmic reticulum (Pkd2)
plasma membrane (Pkd2) cilium (Pkd2) transmembrane transport (Pkd2)
Pkd2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 8 61.52 Quite High
imagery 16 5.00 Very Low Very Low Very Low
Mechanosensation 6 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 31 96.24 Very High Very High Very High
Cyst 35 95.72 Very High Very High Very High
Pancreatic Cyst 1 90.32 High High
Pressure And Volume Under Development 8 89.52 High High
Polycystic Kidney Disease 69 85.52 High High
Cystic Kidney Diseases 9 85.08 High High
Targeted Disruption 11 76.76 Quite High
Apoptosis 17 67.16 Quite High
Congenital Anomalies 8 65.36 Quite High
Disease Progression 3 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, coexpression of TRPV4 significantly increased TRPP2 surface expression (Fig. 2 G), whereas TRPP2 reduced both TRPV4 surface expression and TRPV4 total protein levels (Fig. 2 I).
Positive_regulation (increased) of Gene_expression (expression) of TRPP2
1) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.28 Pain Relevance 0.03
An interesting mouse model with a mutation in the Pkd2 gene (Pkd2?
Positive_regulation (mutation) of Gene_expression (gene) of Pkd2
2) Confidence 0.31 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 1.01 Pain Relevance 0
Membranes were then incubated with PKD1, PKD2, PKD3 antibodies (1?
Positive_regulation (then) of Gene_expression (incubated) of PKD2
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011003 Disease Relevance 0 Pain Relevance 0

General Comments

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